ERAP1

Gene Symbol ERAP1
Entrez Gene 51752
Alt Symbol A-LAP, ALAP, APPILS, ARTS-1, ARTS1, ERAAP, ERAAP1, PILS-AP, PILSAP
Species Human
Gene Type protein-coding
Description endoplasmic reticulum aminopeptidase 1
Other Description adipocyte-derived leucine aminopeptidase|aminopeptidase PILS|aminopeptidase regulator of TNFR1 shedding|endoplasmic reticulum aminopeptidase 1 delta-Exon-11 isoform|endoplasmic reticulum aminopeptidase 1 delta-Exon-13 isoform|endoplasmic reticulum aminopeptidase 1 delta-Exon-14 isoform|endoplasmic reticulum aminopeptidase 1 delta-Exon-15 isoform|endoplasmic reticulum aminopeptidase associated with antigen processing|puromycin-insensitive leucyl-specific aminopeptidase|type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
Swissprots Q9NZ08 Q9UKY2 Q9UHF8 Q8TAD0 Q8NEL4 Q6UWY6 O60278
Accessions EAW96077 EAW96078 EAW96079 Q9NZ08 AB011097 BAA25451 AF106037 AAF07395 AF183569 AAF20384 AF222340 AAF34664 AK094985 AK222873 BAD96593 AK291636 BAF84325 AK310535 AL110186 AY028806 AAK37777 AY028807 AAK37778 AY358590 AAQ88953 BC030775 AAH30775 DA327238 DA704693 DC398730 JX962699 AGR86647 JX962700 AGR86648 JX962701 AGR86649 JX962702 AGR86650 KM357870 AIY60612 KM357871 AIY60613 KM357872 AIY60614 KM357873 AIY60615 KM357874 AIY60616 KM357875 AIY60617 KM357876 AIY60618 KM357877 AIY60619 KM357878 AIY60620 KM357879 AIY60621 KM357880 AIY60622 KM357881 AIY60623 KM357882 AIY60624 KM357883 AIY60625 KM357884 AIY60626 KM357885 AIY60627 KM357886 AIY60628 KM357887 AIY60629 KM357888 AIY60630 KM357889 AIY60631 KM357890 AIY60632 KM357891 AIY60633 LN608057 LN608058 LN608059 LN608060 XM_005272015 XP_005272072 XM_005272016 XP_005272073 XM_011543480 XP_011541782 XM_011543481 XP_011541783 XM_011543482 XP_011541784 XM_011543483 XP_011541785 XM_011543484 XP_011541786 XM_011543485 XP_011541787 XM_011543486 XP_011541788 XM_011543487 XP_011541789 NM_001040458 NP_001035548 NM_001198541 NP_001185470 NM_016442 NP_057526
Function Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. {ECO:0000269|PubMed:15908954, ECO:0000269|PubMed:16286653, ECO:0000269|PubMed:21478864}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305|PubMed:15908954}; Single-pass type II membrane protein {ECO:0000305|PubMed:15908954}.
Tissue Specificity Ubiquitous.

ERAP1 (B-10) - sc-271823 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ERAP1 (B-10): sc-271823. Western blot analysis of ERAP1 expression in Jurkat (A), Hep G2 (B), K-562 (C) and HeLa (D) whole cell lysates.

ERAP1 (H-120) - sc-98254 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ERAP1 (H-120): sc-98254. Western blot analysis of ERAP1 expression in K-562 (A), Jurkat (B), Ramos (C) and THP-1 (D) whole cell lysates.

ERAP1 (L-16) - sc-26884 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ERAP1 (S-19) - sc-26885 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ERAP1 (731) - sc-100727 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
ERAP1 (731): sc-100727. Western blot analysis of ERAP1 expression in A-431 whole cell lysate.

Anti-ARTS1 antibody - ab118432 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab118432 at 12.5ug/ml staining ARTS1 in Formalin-fixed, Paraffin-embedded Human liver tissue by Immunohistochemistry.

Anti-ARTS1 antibody - ab136065 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ARTS1 antibody (ab136065) at 1/500 dilution + HepG2 cell lysate at 30 µg

Anti-ARTS1 antibody - ab57223 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-ARTS1 antibody [EPR6069] - ab124669 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6069
All lanes : Anti-ARTS1 antibody [EPR6069] (ab124669) at 1/1000 dilutionLane 1 : K562 cell lysateLane 2 : HUVEC cell lysateLane 3 : A431 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 2000

Anti-ARTS1 antibody - C-terminal - ab181390 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-ARTS1 antibody - C-terminal (ab181390) at 1 µg/mlLane 2 : Anti-ARTS1 antibody - C-terminal (ab181390) at 2 µg/mlLane 1 : SK-N-SH whole cell lysateLane 2 : SK-N-SH whole cell lysateLysates/proteins at 15 µg per lane.

Anti-ARTS1 / ERAP1 Antibody (aa451-480) - LS-C97467 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of anti-ARTS1 Antibody in Ramos cell line lysates (35 ug/lane). ARTS1 (arrow) was detected using the purified antibody.

Anti-ARTS1 / ERAP1 Antibody (aa832-942) - LS-C307419 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-ARTS1 / ERAP1 Antibody (aa418-467) - LS-C200152 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HepG2 cells using ARTS-1 antibody.

Anti-ARTS1 / ERAP1 Antibody (aa441-490) - LS-C119291 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HepG2/Jurkat/HUVEC cells, using ARTS-1 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-ERAS Antibody (Cys226) - LS-C177378 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of E-Ras (C226) pAb in extracts from Jurkat cells.

Anti-ARTS1 / ERAP1 Antibody (C-Terminus, clone EPR6069) - LS-C138719 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6069
IHC of paraffin-embedded human uterus tissue using anti-ERAP1 antibody.

Anti-ARTS1 / ERAP1 Antibody (Lys467) - LS-C176836 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of ERAP1 (K467) pAb in paraffin-embedded human breast carcinoma tissue.

Anti-ARTS1 / ERAP1 Antibody (Internal) IHC-plus™ - LS-A9785 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ERAP1 / ARTS1 antibody LS-A9785 IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-ARTS1 / ERAP1 Antibody (C-Terminus) IHC-plus™ - LS-A9786 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ERAP1 / ARTS1 antibody LS-A9786 IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-ARTS1 / ERAP1 Antibody (C-Terminus) - LS-C201125 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of ERAP1 in mouse brain tissue with ERAP1 antibody at 5 ug/ml.

Anti-ARTS1 / ERAP1 Antibody (Internal) IHC-plus™ - LS-A8946 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ERAP1 / ARTS1 antibody LS-A8946 IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-ARTS1 / ERAP1 Antibody (Internal) IHC-plus™ - LS-A8945 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ERAP1 / ARTS1 antibody LS-A8945 IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Aminopeptidase PILS/ARTS1 Antibody (6H9) [Unconjugated] - MAB2334 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 6H9
Western blot shows lysates of A431 human epithelial carcinoma cell line. PVDF membrane was probed with 2 µg/mL of Mouse Anti-Human/Mouse Aminopeptidase PILS/ARTS1 Monoclonal Antibody (Catalog # MAB2334) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for Aminopeptidase PILS/ARTS1 at approximately 110 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Aminopeptidase PILS/ARTS1 Antibody - NB100-92405 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Aminopeptidase PILS/ARTS1 Antibody [NB100-92405] - Lane1:THP-1 whole cell lysate. Lane2:NIH-3T3 whole cell lysate. Lane3:Rat kidney tissue lysate.

Aminopeptidase PILS/ARTS1 Antibody (EPR6069) - NBP1-95861 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6069
Western Blot: ARTS1 Antibody (EPR6069) [NBP1-95861] (A) K562, (B) HUVEC, and © A431 cell lysates.
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