ERAP1

Gene Symbol	ERAP1
Entrez Gene	51752
Alt Symbol	A-LAP, ALAP, APPILS, ARTS-1, ARTS1, ERAAP, ERAAP1, PILS-AP, PILSAP
Species	Human
Gene Type	protein-coding
Description	endoplasmic reticulum aminopeptidase 1
Other Description	adipocyte-derived leucine aminopeptidase|aminopeptidase PILS|aminopeptidase regulator of TNFR1 shedding|endoplasmic reticulum aminopeptidase 1 delta-Exon-11 isoform|endoplasmic reticulum aminopeptidase 1 delta-Exon-13 isoform|endoplasmic reticulum aminopeptidase 1 delta-Exon-14 isoform|endoplasmic reticulum aminopeptidase 1 delta-Exon-15 isoform|endoplasmic reticulum aminopeptidase associated with antigen processing|puromycin-insensitive leucyl-specific aminopeptidase|type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
Swissprots	Q9NZ08 Q9UKY2 Q9UHF8 Q8TAD0 Q8NEL4 Q6UWY6 O60278
Accessions	EAW96077 EAW96078 EAW96079 Q9NZ08 AB011097 BAA25451 AF106037 AAF07395 AF183569 AAF20384 AF222340 AAF34664 AK094985 AK222873 BAD96593 AK291636 BAF84325 AK310535 AL110186 AY028806 AAK37777 AY028807 AAK37778 AY358590 AAQ88953 BC030775 AAH30775 DA327238 DA704693 DC398730 JX962699 AGR86647 JX962700 AGR86648 JX962701 AGR86649 JX962702 AGR86650 KM357870 AIY60612 KM357871 AIY60613 KM357872 AIY60614 KM357873 AIY60615 KM357874 AIY60616 KM357875 AIY60617 KM357876 AIY60618 KM357877 AIY60619 KM357878 AIY60620 KM357879 AIY60621 KM357880 AIY60622 KM357881 AIY60623 KM357882 AIY60624 KM357883 AIY60625 KM357884 AIY60626 KM357885 AIY60627 KM357886 AIY60628 KM357887 AIY60629 KM357888 AIY60630 KM357889 AIY60631 KM357890 AIY60632 KM357891 AIY60633 LN608057 LN608058 LN608059 LN608060 XM_005272015 XP_005272072 XM_005272016 XP_005272073 XM_011543480 XP_011541782 XM_011543481 XP_011541783 XM_011543482 XP_011541784 XM_011543483 XP_011541785 XM_011543484 XP_011541786 XM_011543485 XP_011541787 XM_011543486 XP_011541788 XM_011543487 XP_011541789 NM_001040458 NP_001035548 NM_001198541 NP_001185470 NM_016442 NP_057526
Function	Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. {ECO:0000269|PubMed:15908954, ECO:0000269|PubMed:16286653, ECO:0000269|PubMed:21478864}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000305|PubMed:15908954}; Single-pass type II membrane protein {ECO:0000305|PubMed:15908954}.
Tissue Specificity	Ubiquitous.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ERAP1 overexpression lysate - LY402550 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

ERAP1 overexpression lysate - LY421774 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

ERAP1 overexpression lysate - LY425713 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

Aminopeptidase PILS/ARTS1 Overexpression Lysate (Native) - NBP2-04355 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Aminopeptidase PILS/ARTS1 Overexpression Lysate (Native) - NBP2-10627 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Aminopeptidase PILS/ARTS1 Overexpression Lysate (Native) - NBP2-11195 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Panoply™ Human ERAP1 Knockdown Stable Cell Line - CSC-DC005024 from Creative biogene Category Cell Line Species Human

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