ERAP1

Gene Symbol ERAP1
Entrez Gene 51752
Alt Symbol A-LAP, ALAP, APPILS, ARTS-1, ARTS1, ERAAP, ERAAP1, PILS-AP, PILSAP
Species Human
Gene Type protein-coding
Description endoplasmic reticulum aminopeptidase 1
Other Description adipocyte-derived leucine aminopeptidase|aminopeptidase PILS|aminopeptidase regulator of TNFR1 shedding|endoplasmic reticulum aminopeptidase 1 delta-Exon-11 isoform|endoplasmic reticulum aminopeptidase 1 delta-Exon-13 isoform|endoplasmic reticulum aminopeptidase 1 delta-Exon-14 isoform|endoplasmic reticulum aminopeptidase 1 delta-Exon-15 isoform|endoplasmic reticulum aminopeptidase associated with antigen processing|puromycin-insensitive leucyl-specific aminopeptidase|type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
Swissprots Q9NZ08 Q9UKY2 Q9UHF8 Q8TAD0 Q8NEL4 Q6UWY6 O60278
Accessions EAW96077 EAW96078 EAW96079 Q9NZ08 AB011097 BAA25451 AF106037 AAF07395 AF183569 AAF20384 AF222340 AAF34664 AK094985 AK222873 BAD96593 AK291636 BAF84325 AK310535 AL110186 AY028806 AAK37777 AY028807 AAK37778 AY358590 AAQ88953 BC030775 AAH30775 DA327238 DA704693 DC398730 JX962699 AGR86647 JX962700 AGR86648 JX962701 AGR86649 JX962702 AGR86650 KM357870 AIY60612 KM357871 AIY60613 KM357872 AIY60614 KM357873 AIY60615 KM357874 AIY60616 KM357875 AIY60617 KM357876 AIY60618 KM357877 AIY60619 KM357878 AIY60620 KM357879 AIY60621 KM357880 AIY60622 KM357881 AIY60623 KM357882 AIY60624 KM357883 AIY60625 KM357884 AIY60626 KM357885 AIY60627 KM357886 AIY60628 KM357887 AIY60629 KM357888 AIY60630 KM357889 AIY60631 KM357890 AIY60632 KM357891 AIY60633 LN608057 LN608058 LN608059 LN608060 XM_005272015 XP_005272072 XM_005272016 XP_005272073 XM_011543480 XP_011541782 XM_011543481 XP_011541783 XM_011543482 XP_011541784 XM_011543483 XP_011541785 XM_011543484 XP_011541786 XM_011543485 XP_011541787 XM_011543486 XP_011541788 XM_011543487 XP_011541789 NM_001040458 NP_001035548 NM_001198541 NP_001185470 NM_016442 NP_057526
Function Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. {ECO:0000269|PubMed:15908954, ECO:0000269|PubMed:16286653, ECO:0000269|PubMed:21478864}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305|PubMed:15908954}; Single-pass type II membrane protein {ECO:0000305|PubMed:15908954}.
Tissue Specificity Ubiquitous.

ERAP1 CRISPR/Cas9 KO Plasmid (h) - sc-403804 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ERAP1 HDR Plasmid (h) - sc-403804-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ERAP1 Double Nickase Plasmid (h) - sc-403804-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ERAP1 Double Nickase Plasmid (h2) - sc-403804-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ERAP1 CRISPR Activation Plasmid (h) - sc-403804-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ERAP1 CRISPR Activation Plasmid (h2) - sc-403804-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ERAP1 Lentiviral Activation Particles (h) - sc-403804-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ERAP1 Lentiviral Activation Particles (h2) - sc-403804-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ERAP1 siRNA (h) - sc-43577 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ERAP1 shRNA Plasmid (h) - sc-43577-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ERAP1 shRNA (h) Lentiviral Particles - sc-43577-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Aminopeptidase PILS/ARTS1 RNAi - H00051752-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU003021 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7943 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7943 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11364 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11364

ERAP1 siRNA (Human) - CRH9933 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ERAP1 - MBS8203267 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ERAP1 (NM_016442.3) - SHH286777 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ARTS-1(NM_016442.3) - SHG056215 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ARTS-1(NM_001040458.1) - SHG056233 from Creative biogene

Category siRNA
Species Reactivities Human

ERAP1 shRNA Plasmid (Human) - CHH9933 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ERAP1 miRNA 3'UTR clone - MiUTR1H-00613 from Creative biogene

Species Reactivities Human

ERAP1 miRNA 3'UTR clone - MiUTR1H-00614 from Creative biogene

Species Reactivities Human
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