CCNC

Gene Symbol	CCNC
Entrez Gene	892
Alt Symbol	CycC
Species	Human
Gene Type	protein-coding
Description	cyclin C
Other Description	SRB11 homolog|cyclin-C|hSRB11
Swissprots	Q9H543 B4DPZ1 P24863
Accessions	AAC50825 EAW48465 EAW48466 EAW48467 EAW48468 P24863 AB125137 BAD00144 AK130983 AK222768 AK223247 AK291914 BAF84603 AK298558 BAG60753 BC010135 AAH10135 BC026272 AAH26272 BC030159 BC041123 AAH41123 BC050726 BC056153 AAH56153 BM788717 HQ448076 ADQ32557 M74091 XM_006715594 XP_006715657 XM_011536232 XP_011534534 NM_001013399 NP_001013417 NM_005190 NP_005181
Function	Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. {ECO:0000269|PubMed:16595664, ECO:0000269|PubMed:8700522}.
Subcellular Location	Nucleus {ECO:0000305}.
Tissue Specificity	Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CCNC 293 Cell Lysate - 401441 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

CCNC 293 Cell Lysate - 409833 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Cyclin C Overexpression Lysate (Native) - NBL1-08870 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Cyclin C Overexpression Lysate (Native) - NBL1-08869 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

CCNC Over-expression Lysate Product - GWB-5B2A91 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

CCNC Over-expression Lysate Product - GWB-41AA08 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Cyclin C Overexpression Lysate (Denatured) - H00000892-T05 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Cyclin C Overexpression Lysate (Denatured) - H00000892-T04 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human CCNC Knockdown Stable Cell Line - CSC-DC002645 from Creative biogene Category Cell Line Species Human

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