| Gene Symbol | CCNC |
|---|---|
| Entrez Gene | 892 |
| Alt Symbol | CycC |
| Species | Human |
| Gene Type | protein-coding |
| Description | cyclin C |
| Other Description | SRB11 homolog|cyclin-C|hSRB11 |
| Swissprots | Q9H543 B4DPZ1 P24863 |
| Accessions | AAC50825 EAW48465 EAW48466 EAW48467 EAW48468 P24863 AB125137 BAD00144 AK130983 AK222768 AK223247 AK291914 BAF84603 AK298558 BAG60753 BC010135 AAH10135 BC026272 AAH26272 BC030159 BC041123 AAH41123 BC050726 BC056153 AAH56153 BM788717 HQ448076 ADQ32557 M74091 XM_006715594 XP_006715657 XM_011536232 XP_011534534 NM_001013399 NP_001013417 NM_005190 NP_005181 |
| Function | Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. {ECO:0000269|PubMed:16595664, ECO:0000269|PubMed:8700522}. |
| Subcellular Location | Nucleus {ECO:0000305}. |
| Tissue Specificity | Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain. |
cyclin C CRISPR/Cas9 KO Plasmid (h) - sc-402308 from Santa Cruz Biotechnology
|
||||||||
cyclin C HDR Plasmid (h) - sc-402308-HDR from Santa Cruz Biotechnology
|
||||||||
cyclin C Double Nickase Plasmid (h) - sc-402308-NIC from Santa Cruz Biotechnology
|
||||||||
cyclin C Double Nickase Plasmid (h2) - sc-402308-NIC-2 from Santa Cruz Biotechnology
|
||||||||
cyclin C CRISPR Activation Plasmid (h) - sc-402308-ACT from Santa Cruz Biotechnology
|
||||||||
cyclin C CRISPR Activation Plasmid (h2) - sc-402308-ACT-2 from Santa Cruz Biotechnology
|
||||||||
cyclin C Lentiviral Activation Particles (h) - sc-402308-LAC from Santa Cruz Biotechnology
|
||||||||
cyclin C Lentiviral Activation Particles (h2) - sc-402308-LAC-2 from Santa Cruz Biotechnology
|
||||||||
cyclin C siRNA (h) - sc-35132 from Santa Cruz Biotechnology
|
||||||||
cyclin C shRNA Plasmid (h) - sc-35132-SH from Santa Cruz Biotechnology
|
||||||||
cyclin C shRNA (h) Lentiviral Particles - sc-35132-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU047881 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN5631 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5631 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR08596 from Sigma-Aldrich
|
||||||||
CCNC siRNA (Human) - CRH0627 from Cohesion Biosciences
|
||||||||
CCNC - MBS8220130 from MyBioSource
|
||||||||
shRNA set against Human CCNC (NM_005190.3) - SHH257821 from Creative biogene
|
||||||||
shRNA set against Human CCNC(NM_001013399.1) - SHG151939 from Creative biogene
|
||||||||
CCNC shRNA Plasmid (Human) - CHH0627 from Cohesion Biosciences
|
||||||||
CCNC miRNA 3'UTR clone - MiUTR1H-01815 from Creative biogene
|
||||||||
CCNC miRNA 3'UTR clone - MiUTR1H-01816 from Creative biogene
|