Gene Symbol | STEAP1 |
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Entrez Gene | 26872 |
Alt Symbol | PRSS24, STEAP |
Species | Human |
Gene Type | protein-coding |
Description | six transmembrane epithelial antigen of the prostate 1 |
Other Description | metalloreductase STEAP1|six-transmembrane epithelial antigen of prostate 1 |
Swissprots | A4D1E0 Q9UHE8 O95034 |
Accessions | AAD15620 CAJ90613 EAL24166 EAL24167 EAW93749 EAW93750 EAW93751 EAW93752 Q9UHE8 AF186249 AAF17479 AK304076 BAG64983 AK308452 BC011802 AAH11802 BI549469 HQ448213 ADQ32693 NM_012449 NP_036581 |
Function | Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity). {ECO:0000250}. |
Subcellular Location | Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Tissue Specificity | Ubiquitously expressed. Highly expressed in prostate tumors. {ECO:0000269|PubMed:16609065}. |
Top Pathways | Mineral absorption |
STEAP CRISPR/Cas9 KO Plasmid (h) - sc-417620 from Santa Cruz Biotechnology
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STEAP HDR Plasmid (h) - sc-417620-HDR from Santa Cruz Biotechnology
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STEAP Double Nickase Plasmid (h) - sc-417620-NIC from Santa Cruz Biotechnology
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STEAP Double Nickase Plasmid (h2) - sc-417620-NIC-2 from Santa Cruz Biotechnology
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STEAP CRISPR Activation Plasmid (h) - sc-417620-ACT from Santa Cruz Biotechnology
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STEAP CRISPR Activation Plasmid (h2) - sc-417620-ACT-2 from Santa Cruz Biotechnology
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STEAP Lentiviral Activation Particles (h) - sc-417620-LAC from Santa Cruz Biotechnology
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STEAP Lentiviral Activation Particles (h2) - sc-417620-LAC-2 from Santa Cruz Biotechnology
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STEAP siRNA (h) - sc-36571 from Santa Cruz Biotechnology
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STEAP shRNA Plasmid (h) - sc-36571-SH from Santa Cruz Biotechnology
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STEAP shRNA (h) Lentiviral Particles - sc-36571-V from Santa Cruz Biotechnology
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STEAP1 RNAi - H00026872-R01 from Novus Biologicals
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MISSION® esiRNA - EHU108771 from Sigma-Aldrich
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MISSION® esiRNA - EHU111401 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20719 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20719 from Sigma-Aldrich
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STEAP1 siRNA (Human) - CRH8899 from Cohesion Biosciences
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STEAP1 RNAi - H00026872-R02 from Novus Biologicals
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STEAP1 - MBS8206951 from MyBioSource
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shRNA set against Human STEAP1(NM_012449.2) - SHL033420 from Creative biogene
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Human STEAP1 siRNA - orb269401 from Biorbyt
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STEAP1 shRNA Plasmid (Human) - CHH8899 from Cohesion Biosciences
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STEAP1 miRNA 3'UTR clone - MiUTR1H-09991 from Creative biogene
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