| Gene Symbol |
LYNX1
|
| Entrez Gene |
66004
|
| Alt Symbol |
SLURP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Ly6/neurotoxin 1
|
| Other Description |
Ly-6 neurotoxin-like protein 1|SLURP-2|ly-6/neurotoxin-like protein 1|secreted Ly-6/uPAR domain-containing protein 2|secreted Ly-6/uPAR-related protein 2|secreted Ly6/uPAR related protein 2
|
| Swissprots |
G3XAC2 Q86SR0 D3DWI7 Q9BZG9
|
| Accessions |
EAW82299 EAW82301 EAW82302 EAW82303 EAW82304 EAW82306 Q9BZG9 AB081838 BAC56859 AF321824 AAK01642 AI494395 AK123335 AK126845 AL353948 AW449754 AY358417 AAQ88783 AY587277 AAT00512 BC014560 BC047923 BG701653 BI603715 BM172253 BM671222 BQ685632 BU683767 DB501423 HY110957 XM_011517238 XP_011515540 NM_023946 NP_076435 NM_177457 NP_803252 NM_177458 NP_803253 NM_177476 NP_803429 NM_177477 NP_803430
|
| Function |
Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). In brain, isoform 2 modulates functional properties of nAChRs to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha(4)beta(2) nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha(4)beta(2) nAChRs (By similarity). Prevents plasticity in the primary visual cortex late in life (By similarity). In keratinocytes, isoform 3 delays differentiation and prevents apoptosis. {ECO:0000250, ECO:0000269|PubMed:16575903}.
|
| Subcellular Location |
Isoform 3: Secreted.
|
| Tissue Specificity |
Isoform 3 is expressed at highest levels in cervix and esophagus, followed by adult and fetal skin. Expressed at lower levels in brain, lung, stomach, small intestine, colon, rectum, uterus, and thymus. Not detected in spleen nor bone marrow. In the epidermis, predominantly produced by keratinocytes of the suprabasal epidermal compartment (at protein level). In attached gingiva, produced at highest levels by basal cells located in the lowermost epithelial layers (at protein level). Up- regulated 3-fold in psoriatic lesional skin. Detected in serum (at protein level). {ECO:0000269|PubMed:12573258, ECO:0000269|PubMed:16575903}.
|