| Gene Symbol | LYNX1 |
|---|---|
| Entrez Gene | 66004 |
| Alt Symbol | SLURP2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Ly6/neurotoxin 1 |
| Other Description | Ly-6 neurotoxin-like protein 1|SLURP-2|ly-6/neurotoxin-like protein 1|secreted Ly-6/uPAR domain-containing protein 2|secreted Ly-6/uPAR-related protein 2|secreted Ly6/uPAR related protein 2 |
| Swissprots | G3XAC2 Q86SR0 D3DWI7 Q9BZG9 |
| Accessions | EAW82299 EAW82301 EAW82302 EAW82303 EAW82304 EAW82306 Q9BZG9 AB081838 BAC56859 AF321824 AAK01642 AI494395 AK123335 AK126845 AL353948 AW449754 AY358417 AAQ88783 AY587277 AAT00512 BC014560 BC047923 BG701653 BI603715 BM172253 BM671222 BQ685632 BU683767 DB501423 HY110957 XM_011517238 XP_011515540 NM_023946 NP_076435 NM_177457 NP_803252 NM_177458 NP_803253 NM_177476 NP_803429 NM_177477 NP_803430 |
| Function | Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). In brain, isoform 2 modulates functional properties of nAChRs to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha(4)beta(2) nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha(4)beta(2) nAChRs (By similarity). Prevents plasticity in the primary visual cortex late in life (By similarity). In keratinocytes, isoform 3 delays differentiation and prevents apoptosis. {ECO:0000250, ECO:0000269|PubMed:16575903}. |
| Subcellular Location | Isoform 3: Secreted. |
| Tissue Specificity | Isoform 3 is expressed at highest levels in cervix and esophagus, followed by adult and fetal skin. Expressed at lower levels in brain, lung, stomach, small intestine, colon, rectum, uterus, and thymus. Not detected in spleen nor bone marrow. In the epidermis, predominantly produced by keratinocytes of the suprabasal epidermal compartment (at protein level). In attached gingiva, produced at highest levels by basal cells located in the lowermost epithelial layers (at protein level). Up- regulated 3-fold in psoriatic lesional skin. Detected in serum (at protein level). {ECO:0000269|PubMed:12573258, ECO:0000269|PubMed:16575903}. |
Lynx1 CRISPR/Cas9 KO Plasmid (h) - sc-404245 from Santa Cruz Biotechnology
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Lynx1 HDR Plasmid (h) - sc-404245-HDR from Santa Cruz Biotechnology
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Lynx1 Double Nickase Plasmid (h) - sc-404245-NIC from Santa Cruz Biotechnology
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Lynx1 Double Nickase Plasmid (h2) - sc-404245-NIC-2 from Santa Cruz Biotechnology
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Lynx1 CRISPR Activation Plasmid (h) - sc-404245-ACT from Santa Cruz Biotechnology
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Lynx1 CRISPR Activation Plasmid (h2) - sc-404245-ACT-2 from Santa Cruz Biotechnology
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Lynx1 Lentiviral Activation Particles (h) - sc-404245-LAC from Santa Cruz Biotechnology
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Lynx1 Lentiviral Activation Particles (h2) - sc-404245-LAC-2 from Santa Cruz Biotechnology
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Lynx1 siRNA (h) - sc-106911 from Santa Cruz Biotechnology
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Lynx1 shRNA Plasmid (h) - sc-106911-SH from Santa Cruz Biotechnology
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Lynx1 shRNA (h) Lentiviral Particles - sc-106911-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU117021 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12853 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12853 from Sigma-Aldrich
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LYNX1 siRNA (Human) - CRJ2226 from Cohesion Biosciences
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shRNA set against Human LYNX1 (NM_177477.2) - SHH336003 from Creative biogene
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shRNA set against Human LYNX1(NM_177458.1) - SHH168149 from Creative biogene
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shRNA set against Human LYNX1(NM_177457.3) - SHH168203 from Creative biogene
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Human LYNX1 siRNA - orb272727 from Biorbyt
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LYNX1 shRNA Plasmid (Human) - CHJ2226 from Cohesion Biosciences
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LYNX1 miRNA 3'UTR clone - MiUTR1H-05967 from Creative biogene
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LYNX1 miRNA 3'UTR clone - MiUTR1H-05968 from Creative biogene
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LYNX1 miRNA 3'UTR clone - MiUTR3H-08223 from Creative biogene
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