| Gene Symbol |
PLA2G12A
|
| Entrez Gene |
81579
|
| Alt Symbol |
GXII, PLA2G12, ROSSY
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phospholipase A2, group XIIA
|
| Other Description |
GXII sPLA2|group XII secreted phospholipase A2|group XIIA secreted phospholipase A2|group XIIA secretory phospholipase A2|phosphatidylcholine 2-acylhydrolase 12A|phospholipase A2, group XII|sPLA2-XII
|
| Swissprots |
Q9BZ89 Q9BZM1
|
| Accessions |
CAI72089 EAX06246 EAX06247 EAX06248 EAX06249 Q9BZM1 AF306567 AAG50243 AF332892 AAG50289 AK075389 BAC11589 AK313081 BAG35907 AY359024 AAQ89383 BC017218 AAH17218 BI667755 DQ892725 ABM83651 DQ896860 ABM87859 NM_030821 NP_110448
|
| Function |
PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl- phosphatidylcholine or -phosphatidylethanolamine. {ECO:0000269|PubMed:12522102}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:12522102}. Cytoplasm {ECO:0000269|PubMed:12522102}.
|
| Tissue Specificity |
Abundantly expressed in heart, skeletal muscle, kidney, liver and pancreas.
|
| Top Pathways |
Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Ether lipid metabolism, Glycerophospholipid metabolism
|