Gene Symbol | PLA2G12A |
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Entrez Gene | 81579 |
Alt Symbol | GXII, PLA2G12, ROSSY |
Species | Human |
Gene Type | protein-coding |
Description | phospholipase A2, group XIIA |
Other Description | GXII sPLA2|group XII secreted phospholipase A2|group XIIA secreted phospholipase A2|group XIIA secretory phospholipase A2|phosphatidylcholine 2-acylhydrolase 12A|phospholipase A2, group XII|sPLA2-XII |
Swissprots | Q9BZ89 Q9BZM1 |
Accessions | CAI72089 EAX06246 EAX06247 EAX06248 EAX06249 Q9BZM1 AF306567 AAG50243 AF332892 AAG50289 AK075389 BAC11589 AK313081 BAG35907 AY359024 AAQ89383 BC017218 AAH17218 BI667755 DQ892725 ABM83651 DQ896860 ABM87859 NM_030821 NP_110448 |
Function | PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl- phosphatidylcholine or -phosphatidylethanolamine. {ECO:0000269|PubMed:12522102}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:12522102}. Cytoplasm {ECO:0000269|PubMed:12522102}. |
Tissue Specificity | Abundantly expressed in heart, skeletal muscle, kidney, liver and pancreas. |
Top Pathways | Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Ether lipid metabolism, Glycerophospholipid metabolism |
group XIIA sPLA 2 CRISPR/Cas9 KO Plasmid (h) - sc-408023 from Santa Cruz Biotechnology
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group XIIA sPLA 2 HDR Plasmid (h) - sc-408023-HDR from Santa Cruz Biotechnology
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group XIIA sPLA 2 Double Nickase Plasmid (h) - sc-408023-NIC from Santa Cruz Biotechnology
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group XIIA sPLA 2 Double Nickase Plasmid (h2) - sc-408023-NIC-2 from Santa Cruz Biotechnology
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group XIIA sPLA 2 CRISPR Activation Plasmid (h) - sc-408023-ACT from Santa Cruz Biotechnology
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group XIIA sPLA 2 CRISPR Activation Plasmid (h2) - sc-408023-ACT-2 from Santa Cruz Biotechnology
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group XIIA sPLA 2 Lentiviral Activation Particles (h) - sc-408023-LAC from Santa Cruz Biotechnology
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group XIIA sPLA 2 Lentiviral Activation Particles (h2) - sc-408023-LAC-2 from Santa Cruz Biotechnology
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group XIIA sPLA 2 siRNA (h) - sc-89136 from Santa Cruz Biotechnology
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group XIIA sPLA 2 shRNA Plasmid (h) - sc-89136-SH from Santa Cruz Biotechnology
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group XIIA sPLA 2 shRNA (h) Lentiviral Particles - sc-89136-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU108711 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16883 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16883 from Sigma-Aldrich
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PLA2G12A siRNA (Human) - CRJ3012 from Cohesion Biosciences
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Phospholipase A2 XII RNAi - H00081579-R01 from Novus Biologicals
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shRNA set against Human PLA2G12A (NM_030821.4) - SHH376676 from Creative biogene
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PLA2G12A shRNA Plasmid (Human) - CHJ3012 from Cohesion Biosciences
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