Gene Symbol | TNFRSF6B |
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Entrez Gene | 8771 |
Alt Symbol | DCR3, DJ583P15.1.1, M68, M68E, TR6 |
Species | Human |
Gene Type | protein-coding |
Description | tumor necrosis factor receptor superfamily, member 6b, decoy |
Other Description | decoy receptor 3|decoy receptor for Fas ligand|tumor necrosis factor receptor superfamily member 6B |
Swissprots | O95407 |
Accessions | AAF35244 CCQ43788 EAW75242 EAW75243 EAW75244 EAW75246 EAW75247 EAW75248 O95407 AF104419 AAD03056 AF134240 AAD29688 AF217794 AAF33686 AW204999 AY124378 AAM94172 AY124379 AAM94173 AY358279 AAQ88646 BC017065 AAH17065 BC034349 AAH34349 BM759033 NM_003823 NP_003814 NM_032945 |
Function | Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. {ECO:0000269|PubMed:21300286}. |
Subcellular Location | Secreted. |
Tissue Specificity | Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells. |
Top Pathways | Cytokine-cytokine receptor interaction |
DcR3 Antibody - 4758 from Cell Signaling Technology
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DcR3 (A-9) - sc-398892 from Santa Cruz Biotechnology
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DcR3 (F-4) - sc-365755 from Santa Cruz Biotechnology
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DcR3 (G-4) - sc-166176 from Santa Cruz Biotechnology
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DcR3 (H-130) - sc-25464 from Santa Cruz Biotechnology
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DcR3 (C-15) - sc-11643 from Santa Cruz Biotechnology
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DcR3 (T-15) - sc-11642 from Santa Cruz Biotechnology
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DcR3 (4H77) - sc-70955 from Santa Cruz Biotechnology
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DcR3 (6D349) - sc-70956 from Santa Cruz Biotechnology
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DcR3 (37A565) - sc-52918 from Santa Cruz Biotechnology
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Anti-DcR3 antibody - ab8405 from Abcam
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Anti-DcR3 antibody - ab57956 from Abcam
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Anti-DcR3 antibody - ab137183 from Abcam
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Anti-DcR3 antibody - ab107693 from Abcam
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Anti-DcR3 antibody - ab126270 from Abcam
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Anti-DcR3 antibody [37A565] - ab11930 from Abcam
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Anti-TNFRSF6B / DCR3 Antibody (C-Terminus) - LS-C314 from LifeSpan Bioscience
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Anti-TNFRSF6B / DCR3 Antibody - LS-C331044 from LifeSpan Bioscience
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Anti-TNFRSF6B / DCR3 Antibody (clone 7G5) - LS-C133572 from LifeSpan Bioscience
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Anti-TNFRSF6B / DCR3 Antibody (N-Terminus) - LS-C187755 from LifeSpan Bioscience
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Anti-TNFRSF6B / DCR3 Antibody (aa22-48) - LS-C162068 from LifeSpan Bioscience
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Anti-TNFRSF6B / DCR3 Antibody (N-Terminus) - LS-C36143 from LifeSpan Bioscience
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Anti-TNFRSF6B / DCR3 Antibody (C-Terminus) - LS-C90338 from LifeSpan Bioscience
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Anti-TNFRSF6B / DCR3 Antibody (aa24-300, Biotin) - LS-C124937 from LifeSpan Bioscience
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Anti-TNFRSF6B / DCR3 Antibody (aa29-57, AP) - LS-C271872 from LifeSpan Bioscience
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