Gene Symbol | TNFRSF6B |
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Entrez Gene | 8771 |
Alt Symbol | DCR3, DJ583P15.1.1, M68, M68E, TR6 |
Species | Human |
Gene Type | protein-coding |
Description | tumor necrosis factor receptor superfamily, member 6b, decoy |
Other Description | decoy receptor 3|decoy receptor for Fas ligand|tumor necrosis factor receptor superfamily member 6B |
Swissprots | O95407 |
Accessions | AAF35244 CCQ43788 EAW75242 EAW75243 EAW75244 EAW75246 EAW75247 EAW75248 O95407 AF104419 AAD03056 AF134240 AAD29688 AF217794 AAF33686 AW204999 AY124378 AAM94172 AY124379 AAM94173 AY358279 AAQ88646 BC017065 AAH17065 BC034349 AAH34349 BM759033 NM_003823 NP_003814 NM_032945 |
Function | Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. {ECO:0000269|PubMed:21300286}. |
Subcellular Location | Secreted. |
Tissue Specificity | Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells. |
Top Pathways | Cytokine-cytokine receptor interaction |
DcR3 CRISPR/Cas9 KO Plasmid (h) - sc-404980 from Santa Cruz Biotechnology
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DcR3 HDR Plasmid (h) - sc-404980-HDR from Santa Cruz Biotechnology
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DcR3 Double Nickase Plasmid (h) - sc-404980-NIC from Santa Cruz Biotechnology
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DcR3 Double Nickase Plasmid (h2) - sc-404980-NIC-2 from Santa Cruz Biotechnology
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DcR3 CRISPR Activation Plasmid (h) - sc-404980-ACT from Santa Cruz Biotechnology
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DcR3 CRISPR Activation Plasmid (h2) - sc-404980-ACT-2 from Santa Cruz Biotechnology
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DcR3 Lentiviral Activation Particles (h) - sc-404980-LAC from Santa Cruz Biotechnology
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DcR3 Lentiviral Activation Particles (h2) - sc-404980-LAC-2 from Santa Cruz Biotechnology
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DcR3 siRNA (h) - sc-40236 from Santa Cruz Biotechnology
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DcR3 shRNA Plasmid (h) - sc-40236-SH from Santa Cruz Biotechnology
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DcR3 shRNA (h) Lentiviral Particles - sc-40236-V from Santa Cruz Biotechnology
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DcR3/TNFRSF6B RNAi - H00008771-R02 from Novus Biologicals
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DcR3/TNFRSF6B RNAi - H00008771-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN21756 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21756 from Sigma-Aldrich
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TNFRSF6B siRNA (Human) - CRH5776 from Cohesion Biosciences
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TNFRSF6B - MBS8216056 from MyBioSource
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Human TNFRSF6B siRNA - orb266278 from Biorbyt
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TNFRSF6B shRNA Plasmid (Human) - CHH5776 from Cohesion Biosciences
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TNFRSF6B miRNA 3'UTR clone - MiUTR3H-05891 from Creative biogene
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