Gene Symbol | TNFRSF6B |
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Entrez Gene | 8771 |
Alt Symbol | DCR3, DJ583P15.1.1, M68, M68E, TR6 |
Species | Human |
Gene Type | protein-coding |
Description | tumor necrosis factor receptor superfamily, member 6b, decoy |
Other Description | decoy receptor 3|decoy receptor for Fas ligand|tumor necrosis factor receptor superfamily member 6B |
Swissprots | O95407 |
Accessions | AAF35244 CCQ43788 EAW75242 EAW75243 EAW75244 EAW75246 EAW75247 EAW75248 O95407 AF104419 AAD03056 AF134240 AAD29688 AF217794 AAF33686 AW204999 AY124378 AAM94172 AY124379 AAM94173 AY358279 AAQ88646 BC017065 AAH17065 BC034349 AAH34349 BM759033 NM_003823 NP_003814 NM_032945 |
Function | Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. {ECO:0000269|PubMed:21300286}. |
Subcellular Location | Secreted. |
Tissue Specificity | Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells. |
Top Pathways | Cytokine-cytokine receptor interaction |
TNFRSF6B-Over-expression-Lysate - LY14945a from Abgent, a WuXi AppTec company
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TNFRSF6B overexpression lysate - LY418407 from Acris Antibodies
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TNFRSF6B overexpression lysate - LY429165 from Acris Antibodies
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TNFRSF6B 293 Cell Lysate - 408585 from ABBIOTEC
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DcR3/TNFRSF6B Overexpression Lysate (Native) - NBL1-17158 from Novus Biologicals
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DcR3 (h): 293 Lysate - sc-113152 from Santa Cruz Biotechnology
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DcR3 (h2): 293T Lysate - sc-113839 from Santa Cruz Biotechnology
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TNFRSF6B Over-expression Lysate Product - GWB-7ECFCB from Genway Biotech
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TNFRSF6B Over-expression Lysate Product - GWB-639EE6 from Genway Biotech
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Human DCR3 / TNFRSF6B Insect Cell Lysate (WB positive control) - 10224-H02BL-300 from Sino Biological
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DcR3/TNFRSF6B Overexpression Lysate (Native) - NBP2-11314 from Novus Biologicals
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DcR3/TNFRSF6B Overexpression Lysate (Native) - NBP2-10548 from Novus Biologicals
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Human DCR3 Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175294 from Biorbyt
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Panoply™ Human TNFRSF6B Knockdown Stable Cell Line - CSC-DC016368 from Creative biogene
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