NUDT21

Gene Symbol NUDT21
Entrez Gene 11051
Alt Symbol CFIM25, CPSF5
Species Human
Gene Type protein-coding
Description nudix (nucleoside diphosphate linked moiety X)-type motif 21
Other Description CPSF 25 kDa subunit|cleavage and polyadenylation specific factor 5, 25 kD subunit|cleavage and polyadenylation specific factor 5, 25 kDa|cleavage and polyadenylation specificity factor 25 kDa subunit|cleavage and polyadenylation specificity factor subunit 5|cleavage factor Im complex 25 kDa subunit|nucleoside diphosphate-linked moiety X motif 21|nudix motif 21|pre-mRNA cleavage factor Im (25kD)|pre-mRNA cleavage factor Im 25 kDa subunit|pre-mRNA cleavage factor Im, 25kD subunit
Swissprots Q6NE84 Q6IB85 O43809
Accessions EAW82859 EAW82860 O43809 AJ001810 CAA05026 AK312721 BAG35595 AL535307 AM392991 CAL37869 AM393219 CAL38097 BC001403 AAH01403 BX537360 CAD97606 BX647665 CAI46057 CR456919 CAG33200 DQ892142 ABM83068 DQ895336 ABM86262 NM_007006 NP_008937
Function Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export. {ECO:0000269|PubMed:14690600, ECO:0000269|PubMed:20479262, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:21295486, ECO:0000269|PubMed:8626397, ECO:0000269|PubMed:9659921}.
Subcellular Location Nucleus {ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:9659921}. Note=In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles.
Top Pathways mRNA surveillance pathway

NUDT21-Over-expression-Lysate - LY11122a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag NUDT21 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the NUDT21 gene

NUDT21 293 Cell Lysate - 407616 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

NUDT21 Overexpression Lysate (Native) - NBL1-13861 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: NUDT21 Overexpression Lysate (Adult Normal) [NBL1-13861] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NUDT21.

NUDT21 Over-expression Lysate Product - GWB-6D9E75 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human NUDT21 Knockdown Stable Cell Line - CSC-DC010714 from Creative biogene

Category Cell Line
Species Human
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