NUDT21

Gene Symbol	NUDT21
Entrez Gene	11051
Alt Symbol	CFIM25, CPSF5
Species	Human
Gene Type	protein-coding
Description	nudix (nucleoside diphosphate linked moiety X)-type motif 21
Other Description	CPSF 25 kDa subunit|cleavage and polyadenylation specific factor 5, 25 kD subunit|cleavage and polyadenylation specific factor 5, 25 kDa|cleavage and polyadenylation specificity factor 25 kDa subunit|cleavage and polyadenylation specificity factor subunit 5|cleavage factor Im complex 25 kDa subunit|nucleoside diphosphate-linked moiety X motif 21|nudix motif 21|pre-mRNA cleavage factor Im (25kD)|pre-mRNA cleavage factor Im 25 kDa subunit|pre-mRNA cleavage factor Im, 25kD subunit
Swissprots	Q6NE84 Q6IB85 O43809
Accessions	EAW82859 EAW82860 O43809 AJ001810 CAA05026 AK312721 BAG35595 AL535307 AM392991 CAL37869 AM393219 CAL38097 BC001403 AAH01403 BX537360 CAD97606 BX647665 CAI46057 CR456919 CAG33200 DQ892142 ABM83068 DQ895336 ABM86262 NM_007006 NP_008937
Function	Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export. {ECO:0000269|PubMed:14690600, ECO:0000269|PubMed:20479262, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:21295486, ECO:0000269|PubMed:8626397, ECO:0000269|PubMed:9659921}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:9659921}. Note=In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles.
Top Pathways	mRNA surveillance pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NUDT21 full length protein - ab104669 from Abcam Category Protein Source E. coli Species Human

NUDT21 Antibody Blocking Peptide - LS-E14908 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NUDT21 Partial Recombinant Protein - H00011051-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

NUDT21 Recombinant Protein - H00011051-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human NUDT21 Protein - NBP1-51010 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E.coli Species Human

Human NUDT21 protein - orb168957 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

NUDT21 Blocking Peptide - 33R-9098 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

NUDT21 protein (His tag) - 80R-1693 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

CPSF5 (1-227, His-tag) - AR09875PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

CPSF5 (1-227, His-tag) - AR09875PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

CPSF5 - H00011051-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CPSF5 - H00011051-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CPSF5 - H00011051-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CPSF5 - H00011051-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Nudix Type Motif 21, Human Recombinant - 228-12232-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

NUDT21, 1-227aa, Human, His tag, E.coli - 01-1884-21 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

NUDT21 fusion protein - ag0393 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

NUDT21 fusion protein - ag12260 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

NUDT21 Human - ENPS-087 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human NUDT21 - BP000685-ENZ-080 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Human

NUDT21, 1-227aa, Recombinant Protein - GWB-P1103K from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

NUDT21 Human Protein - GWB-BSP268 from Genway Biotech Category Protein Prices $75.00, $165.00, $3,230.00 Sizes 5 μg, 20 μg, 1000 μg Source Escherichia Coli. Species Human

Recombinant Human NUDT21, His-tagged - NUDT21-960H from Creative Biomart Category Protein Source E.coli.

Recombinant Human NUDT21, His-tagged - NUDT21-27532TH from Creative Biomart Category Protein Source E. coli

NUDT21 - JNV-040 from Reagent Proteins Category Protein Prices $364.00, $2,898.00 Sizes 20.00 µg, 1 mg Source E.coli

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