NUDT21

Gene Symbol NUDT21
Entrez Gene 11051
Alt Symbol CFIM25, CPSF5
Species Human
Gene Type protein-coding
Description nudix (nucleoside diphosphate linked moiety X)-type motif 21
Other Description CPSF 25 kDa subunit|cleavage and polyadenylation specific factor 5, 25 kD subunit|cleavage and polyadenylation specific factor 5, 25 kDa|cleavage and polyadenylation specificity factor 25 kDa subunit|cleavage and polyadenylation specificity factor subunit 5|cleavage factor Im complex 25 kDa subunit|nucleoside diphosphate-linked moiety X motif 21|nudix motif 21|pre-mRNA cleavage factor Im (25kD)|pre-mRNA cleavage factor Im 25 kDa subunit|pre-mRNA cleavage factor Im, 25kD subunit
Swissprots Q6NE84 Q6IB85 O43809
Accessions EAW82859 EAW82860 O43809 AJ001810 CAA05026 AK312721 BAG35595 AL535307 AM392991 CAL37869 AM393219 CAL38097 BC001403 AAH01403 BX537360 CAD97606 BX647665 CAI46057 CR456919 CAG33200 DQ892142 ABM83068 DQ895336 ABM86262 NM_007006 NP_008937
Function Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export. {ECO:0000269|PubMed:14690600, ECO:0000269|PubMed:20479262, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:21295486, ECO:0000269|PubMed:8626397, ECO:0000269|PubMed:9659921}.
Subcellular Location Nucleus {ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:9659921}. Note=In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles.
Top Pathways mRNA surveillance pathway

NUDT21 (C-15) - sc-107824 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NUDT21 (T-13) - sc-107826 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NUDT21 (T-13): sc-107826. Western blot analysis of NUDT21 expression in Hep G2 (A), HEK293 (B) and RT-4 (C) whole cell lysates.

NUDT21 (2203C3) - sc-81109 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
NUDT21 (2203C3): sc-81109 Western Blot analysis of human recombinant NUDT21 fusion protein.

Anti-NUDT21 antibody - ab56856 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-NUDT21 Antibody (clone 3F8) - LS-C133674 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3F8
Immunoperoxidase of monoclonal antibody to NUDT21 on formalin-fixed paraffin-embedded human testis. [antibody concentration 3 ug/ml]

Anti-NUDT21 Antibody (clone 2203C3) - LS-C342456 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2203C3
Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-NUDT21 mAb.

Anti-NUDT21 Antibody (aa2-227, clone 1B1) - LS-C340078 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1B1
IHC of paraffin-embedded Carcinoma of Human pancreas tissue using anti-NUDT21 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min)(1:150).

Anti-NUDT21 Antibody (aa2-227, clone 5B3) - LS-C340064 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5B3
IHC of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-NUDT21 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-NUDT21 Antibody (aa2-227, clone 13H1) - LS-C340076 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 13H1
IHC of paraffin-embedded Human endometrium tissue using anti-NUDT21 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min)(1:150).

Anti-NUDT21 Antibody - LS-C73842 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-NUDT21 Antibody - LS-C333358 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using NUDT21 antibody.

Anti-NUDT21 Antibody (N-Terminus) - LS-C30630 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
NUDT21 antibody LS-C30630 was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.

Anti-NUDT21 Antibody (clone 2203C3) - LS-C184411 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2203C3
Immunofluorescent staining using NUDT21 antibody. Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.01% Triton-X100 in PBS. The cells were immunostained with anti-NUDT21 antibody.

NUDT21 Antibody - NBP1-57540 from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NUDT21 Antibody (3F8) - H00011051-M12 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3F8
Immunocytochemistry/Immunofluorescence: NUDT21 Antibody (3F8) [H00011051-M12] - Analysis of monoclonal antibody to NUDT21 on HeLa cell. Antibody concentration 10 ug/ml

NUDT21 Antibody - NBP2-13682 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: NUDT21 Antibody [NBP2-13682] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11 Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG Lane 4: Human Plasma Lane 5: Human liver tissue. Lane 6: Human tonsil tissue

NUDT21 Antibody (2G4-6F11) - H00011051-M01 from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2G4-6F11
Western Blot: NUDT21 Antibody (2G4-6F11) [H00011051-M01] - NUDT21 monoclonal antibody (M01), clone 2G4-6F11. Analysis of NUDT21 expression in human kidney.

NUDT21 Antibody (2G4-6F11) - H00011051-M01A from Novus Biologicals

Prices $349.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 2G4-6F11
Western Blot: NUDT21 Antibody (2G4-6F11) [H00011051-M01A] - NUDT21 monoclonal antibody (M01), clone 2G4-6F11. Western Blot analysis of NUDT21 expression in human kidney.

NUDT21 Antibody (2G4-6F11) - H00011051-M01C from Novus Biologicals

Prices $349.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 2G4-6F11

NUDT21 Antibody (2G4-6F11) - H00011051-M01J from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2G4-6F11

Anti-NUDT21 antibody produced in rabbit - AV40695 from Sigma-Aldrich

Prices $267.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-NUDT21: <B>Cat. No. AV40695</B>: Immunohistochemistry of NUDT21 in Human Intestine tissue with NUDT21 antibody at 4-8 μg/mL.

Monoclonal Anti-NUDT21 antibody produced in mouse - WH0011051M1 from Sigma-Aldrich

Prices $347.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 2G4-6F11

Monoclonal Anti-NUDT21 antibody produced in mouse - SAB1404890 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3F8
<B>Immunohistochemistry</B><BR/>Monoclonal Anti-NUDT21: <B>Cat. No. SAB1404890</B>: Antibody concentration: 3 μg/mL using human testis tissue.

NUDT21 antibody - N-terminal region (ARP40695_T100) - ARP40695_T100 from Aviva Systems Biology

Prices $229.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NUDT21-Antibody-monoclonal-M12 - AT3130a from Abgent, a WuXi AppTec company

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3F8
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (50.71 KDa) .
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