| Gene Symbol |
PHACTR1
|
| Entrez Gene |
221692
|
| Alt Symbol |
RPEL, RPEL1, dJ257A7.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphatase and actin regulator 1
|
| Other Description |
RPEL repeat containing 1
|
| Swissprots |
Q9C0D0 Q5JSJ2 Q3MJ93 A8K1V2
|
| Accessions |
EAW55320 EAW55321 Q9C0D0 AA809685 AB051520 BAB21824 AK090769 BAG52223 AK290017 BAF82706 AK295263 BAG58252 BC047159 BC067280 BC101526 AAI01527 BC101528 AAI01529 BF026507 BQ434462 DA253448 DA330657 XM_005248933 XP_005248990 XM_005248934 XP_005248991 XM_005248935 XP_005248992 XM_005248936 XP_005248993 XM_005248937 XP_005248994 XM_006715021 XP_006715084 XM_011514390 XP_011512692 XM_011514391 XP_011512693 XM_011514392 XP_011512694 NM_001242648 NP_001229577 NM_030948 NP_112210
|
| Function |
Binds actin monomers (G actin) and plays a role in the reorganization of the actin cytoskeleton and in formation of actin stress fibers. Plays a role in cell motility. Plays a role in the formation of tubules by endothelial cells. Regulates PPP1CA activity. Required for normal cell survival. {ECO:0000269|PubMed:21798305, ECO:0000269|PubMed:21939755}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Nucleus {ECO:0000250}. Note=Enriched at synapses (By similarity). Cytoplasmic in resting cells, and is imported into the nucleus upon serum stimulation. Interaction with actin prevents nuclear import (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Detected in umbilical vein endothelial cells. {ECO:0000269|PubMed:21939755}.
|
![Western Blot: PHACTR1 Overexpression Lysate (Adult Normal) [NBL1-14345] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PHACTR1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4685_PHACTR1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14345-img0002.jpg)