| Gene Symbol |
TTK
|
| Entrez Gene |
7272
|
| Alt Symbol |
CT96, ESK, MPH1, MPS1, MPS1L1, PYT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TTK protein kinase
|
| Other Description |
cancer/testis antigen 96|dual specificity protein kinase TTK|monopolar spindle 1 kinase|monopolar spindle 1-like 1|phosphotyrosine picked threonine kinase|phosphotyrosine picked threonine-protein kinase
|
| Swissprots |
Q5TCS0 Q15272 Q9NTM0 P33981 B2RDW2 E1P543 Q9BW51 A8K8U5
|
| Accessions |
CAV33297 CCO75436 CCO75438 CCQ77693 CCQ77702 CCQ77711 CCQ77720 CDH48199 CDH61621 CDH61675 CDH61694 CDH88992 CDH92530 CDH92544 CDH92555 CDH92802 CDH92899 CDI44674 CDI44683 EAW48699 EAW48700 P33981 AK095599 AK292460 BAF85149 AK315696 BAG38059 AU154042 AX775733 CAE11566 BC000633 AAH00633 BC032858 AAH32858 DA853919 DQ891960 ABM82886 DQ895150 ABM86076 X70500 CAA49912 XM_011536099 XP_011534401 XM_011536100 XP_011534402 NM_001166691 NP_001160163 NM_003318 NP_003309
|
| Function |
Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint. {ECO:0000269|PubMed:18243099}.
|
| Tissue Specificity |
Present in rapidly proliferating cell lines.
|
| Top Pathways |
Cell cycle
|