| Gene Symbol |
CHAC1
|
| Entrez Gene |
79094
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ChaC glutathione-specific gamma-glutamylcyclotransferase 1
|
| Other Description |
ChaC, cation transport regulator homolog 1|ChaC, cation transport regulator-like 1|blocks Notch protein|botch|cation transport regulator-like protein 1|gamma-GCG 1|gamma-GCT acting on glutathione homolog 1|glutathione-specific gamma-glutamylcyclotransferase 1
|
| Swissprots |
Q0VIA0 Q9BUX1
|
| Accessions |
EAW92467 Q9BUX1 AY702027 AAW23972 BC001683 AAH01683 BC001847 AAH01847 BC019625 AAH19625 BM665296 BM784841 BQ900544 CB529304 NM_001142776 NP_001136248 NM_024111 NP_077016
|
| Function |
Catalyzes the cleavage glutathione into 5-oxoproline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution (PubMed:23070364). Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366). {ECO:0000269|PubMed:19109178, ECO:0000269|PubMed:22445366, ECO:0000269|PubMed:23070364}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:19109178}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q8R3J5}.
|
![Western Blot: CHAC1 Overexpression Lysate (Adult Normal) [NBP2-06348] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CHAC1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10639_CHAC1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06348-img0001.jpg)