CHAC1

Gene Symbol CHAC1
Entrez Gene 79094
Alt Symbol -
Species Human
Gene Type protein-coding
Description ChaC glutathione-specific gamma-glutamylcyclotransferase 1
Other Description ChaC, cation transport regulator homolog 1|ChaC, cation transport regulator-like 1|blocks Notch protein|botch|cation transport regulator-like protein 1|gamma-GCG 1|gamma-GCT acting on glutathione homolog 1|glutathione-specific gamma-glutamylcyclotransferase 1
Swissprots Q0VIA0 Q9BUX1
Accessions EAW92467 Q9BUX1 AY702027 AAW23972 BC001683 AAH01683 BC001847 AAH01847 BC019625 AAH19625 BM665296 BM784841 BQ900544 CB529304 NM_001142776 NP_001136248 NM_024111 NP_077016
Function Catalyzes the cleavage glutathione into 5-oxoproline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution (PubMed:23070364). Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366). {ECO:0000269|PubMed:19109178, ECO:0000269|PubMed:22445366, ECO:0000269|PubMed:23070364}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:19109178}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q8R3J5}.

CHAC1 (E-15) - sc-133320 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
CHAC1 (E-15): sc-133320. Western blot analysis of CHAC1 expression in HeLa (A), NIH/3T3 (B), MIA PaCa-2 (C) and C2C12 (D) whole cell lysates and mouse pancreas tissue extract (E).

CHAC1 (H-42) - sc-382544 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

CHAC1 (T-12) - sc-133321 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
CHAC1 (T-12): sc-133321. Western blot analysis of CHAC1 expression in MIA PaCa-2 whole cell lysate.

Anti-CHAC1 antibody - ab105101 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-CHAC1 antibody - ab184982 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Lane 1 : Lanes 2 - 3 : Anti-CHAC1 antibody (ab184982)Lane 1 : MarkerLane 2 : HEK293T cell lysate - vector only transfectedLane 3 : HEK293T cell lysate - overexpressing CHAC1 with a C-terminal myc-DDK tag (~3.1kDa)

Anti-CHAC1 antibody [1G2] - ab180380 from Abcam

Prices $357.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G2
All lanes : Anti-CHAC1 antibody [1G2] (ab180380) at 1/4000 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cells transfected with pCMV6-ENTRY CHAC1 cDNALysates/proteins at 5 µg per lane.

Anti-CHAC1 / MGC4504 Antibody (clone 1E2) - LS-C338346 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1E2
IHC of paraffin-embedded Carcinoma of Human pancreas tissue using anti-CHAC1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-CHAC1 / MGC4504 Antibody - LS-C340960 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CHAC1 / MGC4504 Antibody (aa188-237) - LS-C80516 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-CHAC1 / MGC4504 Antibody (clone 4A11) - LS-C338345 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4A11
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CHAC1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CHAC1.

Anti-CHAC1 / MGC4504 Antibody (clone 1E3) - LS-C338334 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1E3
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CHAC1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CHAC1.

Anti-CHAC1 / MGC4504 Antibody (clone 4B3) - LS-C338344 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4B3
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CHAC1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CHAC1.

Anti-CHAC1 / MGC4504 Antibody (clone 1G2) - LS-C340622 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G2
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CHAC1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CHAC1.

Anti-CHAC1 / MGC4504 Antibody (clone 1G7) - LS-C338335 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G7
Anti-CHAC1 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CHAC1.

Anti-CHAC1 / MGC4504 Antibody (clone 1G1) - LS-C338320 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G1
Anti-CHAC1 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CHAC1.

CHAC1 Antibody - NBP2-30983 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CHAC1 Antibody [NBP2-30983] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10Lane 2: Negative control (vector only transfected HEK293T lysate)Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY411345)

CHAC1 Antibody - NBP1-57685 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CHAC1 Antibody - NBP2-30433 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: CHAC1 Antibody [NBP2-30433] - Staining of human kidney shows strong cytoplasmic positivity in cells in tubules.

CHAC1 Polyclonal Antibody - bs-6795R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti CHAC1 Polyclonal Antibody, Unconjugated (bs-6795R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Anti-CHAC1 antibody produced in rabbit - HPA043505 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CHAC1: <B>Cat. No. HPA043505</B>: Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in cells in tubules.

Anti-CHAC1 antibody produced in rabbit - AV42623 from Sigma-Aldrich

Prices $316.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: 721_B (<B>Cat. No. AV42623</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 1 μg/mL in cell type 721_B

Anti-CHAC1 antibody produced in rabbit - SAB2700669 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CHAC1: <B>Cat. No. SAB2700669</B>: Western Blot analysis of CHAC1 in extracts from <B>Lanes</B><BR/>A. HeLa treated with tunicamycin using <B>Cat. No. SAB2700669</B> at a 1:500 dilution.

Anti-CHAC1 antibody produced in rabbit - HPA042708 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CHAC1: <B>Cat. No. HPA042708</B>: Immunohistochemical staining of human lateral ventricle shows strong cytoplasmic positivity in neuronal cells.

CHAC1 antibody - C-terminal region (ARP42623_P050) - ARP42623_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CHAC1 antibody [N1C3] - GTX120775 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-CHAC1 antibody [N1C3] used in Western blot. GTX120775
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