CHAC1

Gene Symbol	CHAC1
Entrez Gene	79094
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	ChaC glutathione-specific gamma-glutamylcyclotransferase 1
Other Description	ChaC, cation transport regulator homolog 1|ChaC, cation transport regulator-like 1|blocks Notch protein|botch|cation transport regulator-like protein 1|gamma-GCG 1|gamma-GCT acting on glutathione homolog 1|glutathione-specific gamma-glutamylcyclotransferase 1
Swissprots	Q0VIA0 Q9BUX1
Accessions	EAW92467 Q9BUX1 AY702027 AAW23972 BC001683 AAH01683 BC001847 AAH01847 BC019625 AAH19625 BM665296 BM784841 BQ900544 CB529304 NM_001142776 NP_001136248 NM_024111 NP_077016
Function	Catalyzes the cleavage glutathione into 5-oxoproline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution (PubMed:23070364). Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366). {ECO:0000269|PubMed:19109178, ECO:0000269|PubMed:22445366, ECO:0000269|PubMed:23070364}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:19109178}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q8R3J5}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CHAC1 Blocking Peptide - 33R-9229 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CHAC1 Blocking Peptide - abx063972 from Abbexa Category Peptide Species Human, Mouse, Rat

CHAC1 fusion protein - ag7527 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

CHAC1 fusion protein - ag7360 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CHAC1 Blocking Peptide - CBP2778 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Recombinant Human Cation transport regulator-like protein 1(CHAC1) - CSB-YP883606HU CSB-EP883606HU CSB-BP883606HU CSB-MP883606HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CHAC1 (transcript variant 1) - TP300912 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

CHAC1 (transcript variant 2) - TP327708 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Cation transport regulator-like protein 1 (CHAC1), Recombinant Protein - MBS1456137 from MyBioSource Category Protein Prices $1,015.00, $1,015.00, $1,245.00, $1,245.00, $1,565.00, $1,565.00, $2,030.00, $2,030.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

CHAC1 Recombinant Protein Antigen - NBP2-30433PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CHAC1 Peptide, Human - M34GP03056H from Creative Peptides Category Peptide Source Synthetic. Species Human

ChaC1 - AF1754 from Creative Peptides Category Peptide Source Chassalia chartacea (or Chassalia curviflora)

CHAC1 Recombinant Protein Antigen - NBP2-30983PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Source E.coli Species Human

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