CHAC1

Gene Symbol CHAC1
Entrez Gene 79094
Alt Symbol -
Species Human
Gene Type protein-coding
Description ChaC glutathione-specific gamma-glutamylcyclotransferase 1
Other Description ChaC, cation transport regulator homolog 1|ChaC, cation transport regulator-like 1|blocks Notch protein|botch|cation transport regulator-like protein 1|gamma-GCG 1|gamma-GCT acting on glutathione homolog 1|glutathione-specific gamma-glutamylcyclotransferase 1
Swissprots Q0VIA0 Q9BUX1
Accessions EAW92467 Q9BUX1 AY702027 AAW23972 BC001683 AAH01683 BC001847 AAH01847 BC019625 AAH19625 BM665296 BM784841 BQ900544 CB529304 NM_001142776 NP_001136248 NM_024111 NP_077016
Function Catalyzes the cleavage glutathione into 5-oxoproline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution (PubMed:23070364). Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366). {ECO:0000269|PubMed:19109178, ECO:0000269|PubMed:22445366, ECO:0000269|PubMed:23070364}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:19109178}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q8R3J5}.

CHAC1 CRISPR/Cas9 KO Plasmid (h) - sc-403197 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHAC1 HDR Plasmid (h) - sc-403197-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHAC1 Double Nickase Plasmid (h) - sc-403197-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHAC1 Double Nickase Plasmid (h2) - sc-403197-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHAC1 CRISPR Activation Plasmid (h) - sc-403197-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHAC1 CRISPR Activation Plasmid (h2) - sc-403197-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHAC1 Lentiviral Activation Particles (h) - sc-403197-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHAC1 Lentiviral Activation Particles (h2) - sc-403197-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHAC1 siRNA (h) - sc-90164 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CHAC1 shRNA Plasmid (h) - sc-90164-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CHAC1 shRNA (h) Lentiviral Particles - sc-90164-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU043501 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6025 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6025 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CHAC1 siRNA (Human) - CRJ2309 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CHAC1 - MBS8213394 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CHAC1 CRISPR/Cas9 KO Plasmid (h2) - sc-403197-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHAC1 HDR Plasmid (h2) - sc-403197-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human CHAC1 (NM_024111.3) - SHH262629 from Creative biogene

Category siRNA
Species Reactivities Human

Human CHAC1 siRNA - orb272810 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CHAC1 shRNA Plasmid (Human) - CHJ2309 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CHAC1 miRNA 3'UTR clone - MiUTR3H-13320 from Creative biogene

Species Reactivities Human

CHAC1 miRNA 3'UTR clone - MiUTR3H-13321 from Creative biogene

Species Reactivities Human
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