Gene Symbol | MED26 |
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Entrez Gene | 9441 |
Alt Symbol | CRSP7, CRSP70 |
Species | Human |
Gene Type | protein-coding |
Description | mediator complex subunit 26 |
Other Description | ARC70|CRSP complex subunit 7|activator-recruited cofactor 70 kDa component|cofactor required for Sp1 transcriptional activation subunit 7|cofactor required for Sp1 transcriptional activation, subunit 7 (70kD)|cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa|mediator of RNA polymerase II transcription subunit 26|transcriptional coactivator CRSP70 |
Swissprots | Q0VGB6 A1A4S3 O95402 |
Accessions | EAW84554 O95402 AF104253 AAD12722 AK128435 AK313778 BAG36516 BC047040 BC063628 BC105951 BC105952 BC105953 BC110430 AAI10431 BC127214 BC127215 AAI27216 BC143047 NM_004831 NP_004822 |
Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. |
Subcellular Location | Nucleus {ECO:0000305}. |
CRSP70 CRISPR/Cas9 KO Plasmid (h) - sc-402381 from Santa Cruz Biotechnology
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CRSP70 HDR Plasmid (h) - sc-402381-HDR from Santa Cruz Biotechnology
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CRSP70 Double Nickase Plasmid (h) - sc-402381-NIC from Santa Cruz Biotechnology
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CRSP70 Double Nickase Plasmid (h2) - sc-402381-NIC-2 from Santa Cruz Biotechnology
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CRSP70 CRISPR Activation Plasmid (h) - sc-402381-ACT from Santa Cruz Biotechnology
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CRSP70 CRISPR Activation Plasmid (h2) - sc-402381-ACT-2 from Santa Cruz Biotechnology
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CRSP70 Lentiviral Activation Particles (h) - sc-402381-LAC from Santa Cruz Biotechnology
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CRSP70 Lentiviral Activation Particles (h2) - sc-402381-LAC-2 from Santa Cruz Biotechnology
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CRSP70 siRNA (h) - sc-38573 from Santa Cruz Biotechnology
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CRSP70 shRNA Plasmid (h) - sc-38573-SH from Santa Cruz Biotechnology
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CRSP70 shRNA (h) Lentiviral Particles - sc-38573-V from Santa Cruz Biotechnology
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MED26 RNAi - H00009441-R01 from Novus Biologicals
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MISSION® esiRNA - EHU143921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13175 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13175 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08086 from Sigma-Aldrich
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MED26 siRNA (Human) - CRH6260 from Cohesion Biosciences
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shRNA set against Human MED26 (NM_004831.3) - SHH340047 from Creative biogene
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shRNA set against Human CRSP7(NM_004831.3) - SHH000811 from Creative biogene
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Human MED26 siRNA - orb266762 from Biorbyt
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MED26 shRNA Plasmid (Human) - CHH6260 from Cohesion Biosciences
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MED26 miRNA 3'UTR clone - MiUTR1H-02440 from Creative biogene
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