| Gene Symbol |
CDC42SE2
|
| Entrez Gene |
56990
|
| Alt Symbol |
SPEC2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CDC42 small effector 2
|
| Other Description |
CDC42 small effector protein 2|non-kinase Cdc42 effector protein SPEC2|small effector of CDC42 protein 2
|
| Swissprots |
Q9NRR3 Q4KMT9 B2R622
|
| Accessions |
EAW62372 EAW62373 Q9NRR3 AF131831 AF189692 AAF87598 AI440226 AK025620 AK312406 BAG35319 BC023555 BC050430 BC058909 BC096703 AAH96703 BC096738 AAH96738 BC098349 AAH98349 BI460220 BI522591 CB135092 DA321488 NM_001038702 NP_001033791 NM_020240 NP_064625
|
| Function |
Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages. {ECO:0000269|PubMed:10816584, ECO:0000269|PubMed:15840583}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Cell projection, phagocytic cup. Note=Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages.
|
| Tissue Specificity |
Widely expressed. Expressed at higher level in T-lymphocytes. Highly expressed in CCRF-CEM T-lymphocytes, Jurkat T-lymphocytes, and Raji B-lymphocytes compared (at protein level). {ECO:0000269|PubMed:15840583}.
|
![Western Blot: CDC42SE2 Overexpression Lysate (Adult Normal) [NBP2-08562] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CDC42SE2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3303_CDC42SE2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-08562-img0001.jpg)
![Western Blot: CDC42SE2 Overexpression Lysate (Adult Normal) [NBP2-09199] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CDC42SE2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1062_CDC42SE2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-09199-img0001.jpg)
![Western Blot: CDC42SE2 Overexpression Lysate (Adult Normal) [NBP2-06671] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CDC42SE2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5396_CDC42SE2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06671-img0001.jpg)