NLRX1

Gene Symbol NLRX1
Entrez Gene 79671
Alt Symbol CLR11.3, DLNB26, NOD26, NOD5, NOD9
Species Human
Gene Type protein-coding
Description NLR family member X1
Other Description NLR family, X1|NOD-like receptor X1|caterpiller protein 11.3|nucleotide-binding oligomerization domain protein 26|nucleotide-binding oligomerization domain protein 5|nucleotide-binding oligomerization domain protein 9|nucleotide-binding oligomerization domain, leucine rich repeat containing X1
Swissprots B3KPK2 A8K6Q1 Q96D51 Q7RTR3 Q9H724 Q86UT6 B3KTA2
Accessions EAW67467 EAW67468 EAW67469 Q86UT6 AB094095 BAC76049 AK025131 BAB15075 AK056454 BAG51714 AK095247 BAG53014 AK225223 AK291716 BAF84405 AK303002 BAH13875 AL049456 CAH56420 AY245437 AAP31240 BC013199 AAH13199 BC023974 BC110890 AAI10891 BK001111 DAA01244 BX647705 DA107044 DA441499 EF452237 ABO40480 XM_005271669 XP_005271726 XM_005271670 XP_005271727 XM_005271671 XP_005271728 XM_005271672 XP_005271729 XM_006718904 XP_006718967 XM_011542980 XP_011541282 NM_001282143 NP_001269072 NM_001282144 NP_001269073 NM_001282358 NP_001269287 NM_024618 NP_078894 NM_170722
Function Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF- Kappa-B and type 1 interferon signaling pathways, but enhances NF- Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). {ECO:0000269|PubMed:18200010, ECO:0000269|PubMed:18219313}.
Subcellular Location Mitochondrion outer membrane {ECO:0000269|PubMed:18200010, ECO:0000269|PubMed:18219313}.
Tissue Specificity Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL-60, Raji and Jurkat cell lines (at protein level). {ECO:0000269|PubMed:15952891, ECO:0000269|PubMed:18200010, ECO:0000269|PubMed:18219313}.
Top Pathways RIG-I-like receptor signaling pathway, Influenza A

NLRX1 (D4M3Z) Rabbit mAb - 13829 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D4M3Z
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a construct expressing full-length human NLRX1 (hNLRX1, +), using NLRX1 (D4M3Z) Rabbit mAb.

NLRX1 Antibody - 8583 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using NLRX1 Antibody.

NOD9 (F-2) - sc-374514 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NOD9 (F-2): sc-374514. Western blot analysis of NOD9 expression in HeLa whole cell lysate.

NOD9 (D-14) - sc-131636 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NOD9 (H-142) - sc-292091 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-NLRX1 antibody - ab105412 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of NLRX1 in rat spleen tissue with ab105412 at 20 ug/mL.

Anti-NLRX1 Antibody (aa248-297) - LS-C201780 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of mouse neuroblastoma tumor. Lane 1: 35 ug mouse neuroblastoma cells with empty vector. Lane 2: 35 ug mouse neuroblastoma cells with NLRX1 siRNA. NLRX1 Antibody Dilution 1:1000.

Anti-NLRX1 Antibody - LS-C333745 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of HEK293 cell line, using NLRX1 antibody.

Anti-NLRX1 Antibody (C-Terminus) - LS-C169761 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-NLRX1 Antibody (aa405-418) - LS-C139583 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
NLRX1 antibody (2 ug/ml) staining of Human Breast cancer lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-NLRX1 Antibody (N-Terminus) - LS-C115894 from LifeSpan Bioscience

Prices $345.00, $1,035.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of NOD5 in rat spleen tissue with NOD5 antibody at 20 ug/ml.

Anti-NLRX1 Antibody (aa580-630) IHC-plus™ - LS-B8005 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-NLRX1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8005 concentration 10 ug/ml.

NLRX1 Antibody - NBP2-27198 from Novus Biologicals

Prices $99.00, $299.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: NLRX1 Antibody [NBP2-27198] - analysis of NLRX1 in mouse heart tissue lysate in the 1) absence and 2) presence of immunizing peptide using this antibody. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

NLRX1 Antibody - NBP1-76287 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: NLRX1 Antibody [NBP1-76287] - Rat spleen tissue cell lysate with NOD5 antibody at (A) 1 and (B) 2 ug/mL.

NLRX1 Antibody - NBP1-84438 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: NLRX1 Antibody [NBP1-84438] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells)<br/>Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells)

NLRX1 Antibody - NBP1-49838 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: NLRX1 Antibody [NBP1-49838] - Analysis of NLRX1 in Human Breast cancer lysate (35ug protein in RIPA buffer) using this antibody at 2ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.

NLRX1 Polyclonal Antibody - bs-8511R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded human breast carcinoma labeled with Anti-NLRX1 Polyclonal Antibody, Unconjugated (bs-8511R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Anti-NLRX1 antibody produced in rabbit - HPA038630 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-NLRX1: <B>Cat. No. HPA038630</B>: Immunohistochemical staining of human heart muscle shows strong cytoplasmic positivity in myocytes.

Anti-NOD5 antibody produced in rabbit - SAB3500546 from Sigma-Aldrich

Prices $347.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-NOD5: <B>Cat. No. SAB3500546</B>: NOD5 in rat spleen tissue cell lysate with NOD5 antibody at (A) 1 and (B) 2 μg/mL.

NLRX1 Antibody - N-terminal region (ARP65181_P050) - ARP65181_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NLRX1 Antibody - C-terminal region (ARP65182_P050) - ARP65182_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NLRX1--NOD9-Antibody-internal-region - AF3143a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF3143a (2 µg/ml) staining of Human Breast cancer lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

NLRX1 antibody, Internal - GTX88038 from GeneTex

Prices $319.00
Sizes 100 μg
Host Goat
Clonality Polyclonal
Anti-NLRX1 / NOD9 antibody, Internal used in Western blot. GTX88038

NLRX1 antibody - GTX84999 from GeneTex

Prices $319.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Anti-NOD5 antibody used in ICC/IF. GTX84999

NLRX1 Antibody (OABF01859) - OABF01859 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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