NLRX1

Gene Symbol	NLRX1
Entrez Gene	79671
Alt Symbol	CLR11.3, DLNB26, NOD26, NOD5, NOD9
Species	Human
Gene Type	protein-coding
Description	NLR family member X1
Other Description	NLR family, X1|NOD-like receptor X1|caterpiller protein 11.3|nucleotide-binding oligomerization domain protein 26|nucleotide-binding oligomerization domain protein 5|nucleotide-binding oligomerization domain protein 9|nucleotide-binding oligomerization domain, leucine rich repeat containing X1
Swissprots	B3KPK2 A8K6Q1 Q96D51 Q7RTR3 Q9H724 Q86UT6 B3KTA2
Accessions	EAW67467 EAW67468 EAW67469 Q86UT6 AB094095 BAC76049 AK025131 BAB15075 AK056454 BAG51714 AK095247 BAG53014 AK225223 AK291716 BAF84405 AK303002 BAH13875 AL049456 CAH56420 AY245437 AAP31240 BC013199 AAH13199 BC023974 BC110890 AAI10891 BK001111 DAA01244 BX647705 DA107044 DA441499 EF452237 ABO40480 XM_005271669 XP_005271726 XM_005271670 XP_005271727 XM_005271671 XP_005271728 XM_005271672 XP_005271729 XM_006718904 XP_006718967 XM_011542980 XP_011541282 NM_001282143 NP_001269072 NM_001282144 NP_001269073 NM_001282358 NP_001269287 NM_024618 NP_078894 NM_170722
Function	Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF- Kappa-B and type 1 interferon signaling pathways, but enhances NF- Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). {ECO:0000269|PubMed:18200010, ECO:0000269|PubMed:18219313}.
Subcellular Location	Mitochondrion outer membrane {ECO:0000269|PubMed:18200010, ECO:0000269|PubMed:18219313}.
Tissue Specificity	Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL-60, Raji and Jurkat cell lines (at protein level). {ECO:0000269|PubMed:15952891, ECO:0000269|PubMed:18200010, ECO:0000269|PubMed:18219313}.
Top Pathways	RIG-I-like receptor signaling pathway, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NLRX1 overexpression lysate - LY403011 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

NLRX1 293 Cell Lysate - 402619 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

NLRX1 Overexpression Lysate (Native) - NBL1-13677 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

NLRX1 Over-expression Lysate Product - GWB-100497 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Panoply™ Human NLRX1 Knockdown Stable Cell Line - CSC-DC010446 from Creative biogene Category Cell Line Species Human

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