| Gene Symbol | NLRX1 |
|---|---|
| Entrez Gene | 79671 |
| Alt Symbol | CLR11.3, DLNB26, NOD26, NOD5, NOD9 |
| Species | Human |
| Gene Type | protein-coding |
| Description | NLR family member X1 |
| Other Description | NLR family, X1|NOD-like receptor X1|caterpiller protein 11.3|nucleotide-binding oligomerization domain protein 26|nucleotide-binding oligomerization domain protein 5|nucleotide-binding oligomerization domain protein 9|nucleotide-binding oligomerization domain, leucine rich repeat containing X1 |
| Swissprots | B3KPK2 A8K6Q1 Q96D51 Q7RTR3 Q9H724 Q86UT6 B3KTA2 |
| Accessions | EAW67467 EAW67468 EAW67469 Q86UT6 AB094095 BAC76049 AK025131 BAB15075 AK056454 BAG51714 AK095247 BAG53014 AK225223 AK291716 BAF84405 AK303002 BAH13875 AL049456 CAH56420 AY245437 AAP31240 BC013199 AAH13199 BC023974 BC110890 AAI10891 BK001111 DAA01244 BX647705 DA107044 DA441499 EF452237 ABO40480 XM_005271669 XP_005271726 XM_005271670 XP_005271727 XM_005271671 XP_005271728 XM_005271672 XP_005271729 XM_006718904 XP_006718967 XM_011542980 XP_011541282 NM_001282143 NP_001269072 NM_001282144 NP_001269073 NM_001282358 NP_001269287 NM_024618 NP_078894 NM_170722 |
| Function | Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF- Kappa-B and type 1 interferon signaling pathways, but enhances NF- Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). {ECO:0000269|PubMed:18200010, ECO:0000269|PubMed:18219313}. |
| Subcellular Location | Mitochondrion outer membrane {ECO:0000269|PubMed:18200010, ECO:0000269|PubMed:18219313}. |
| Tissue Specificity | Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL-60, Raji and Jurkat cell lines (at protein level). {ECO:0000269|PubMed:15952891, ECO:0000269|PubMed:18200010, ECO:0000269|PubMed:18219313}. |
| Top Pathways | RIG-I-like receptor signaling pathway, Influenza A |
NOD9 CRISPR/Cas9 KO Plasmid (h) - sc-402937 from Santa Cruz Biotechnology
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NOD9 HDR Plasmid (h) - sc-402937-HDR from Santa Cruz Biotechnology
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NOD9 Double Nickase Plasmid (h) - sc-402937-NIC from Santa Cruz Biotechnology
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NOD9 Double Nickase Plasmid (h2) - sc-402937-NIC-2 from Santa Cruz Biotechnology
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NOD9 CRISPR Activation Plasmid (h) - sc-402937-ACT from Santa Cruz Biotechnology
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NOD9 CRISPR Activation Plasmid (h2) - sc-402937-ACT-2 from Santa Cruz Biotechnology
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NOD9 Lentiviral Activation Particles (h) - sc-402937-LAC from Santa Cruz Biotechnology
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NOD9 Lentiviral Activation Particles (h2) - sc-402937-LAC-2 from Santa Cruz Biotechnology
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NOD9 siRNA (h) - sc-96800 from Santa Cruz Biotechnology
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NOD9 shRNA Plasmid (h) - sc-96800-SH from Santa Cruz Biotechnology
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NOD9 shRNA (h) Lentiviral Particles - sc-96800-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU111901 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15362 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15362 from Sigma-Aldrich
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NLRX1 siRNA (Human) - CRJ2474 from Cohesion Biosciences
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shRNA set against Human NLRX1 (NM_024618.2) - SHH353076 from Creative biogene
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shRNA set against Human NLRX1(NM_170722.1) - SHR013400 from Creative biogene
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shRNA set against Human NLRX1(NM_024618.2) - SHR013578 from Creative biogene
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Human NLRX1 siRNA - orb272975 from Biorbyt
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NLRX1 shRNA Plasmid (Human) - CHJ2474 from Cohesion Biosciences
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NLRX1 miRNA 3'UTR clone - MiUTR1H-06806 from Creative biogene
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NLRX1 miRNA 3'UTR clone - MiUTR1H-06807 from Creative biogene
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