PCSK1

Gene Symbol PCSK1
Entrez Gene 5122
Alt Symbol BMIQ12, NEC1, PC1, PC3, SPC3
Species Human
Gene Type protein-coding
Description proprotein convertase subtilisin/kexin type 1
Other Description neuroendocrine convertase 1|prohormone convertase 1|prohormone convertase 3
Swissprots P78478 B7Z8T7 Q92532 E9PHA1 P29120
Accessions AAA73788 BAA11133 EAW96062 EAW96063 P29120 AB208874 BAD92111 AK303888 BAH14073 AK308575 BC031211 BC130295 AAI30296 BC136486 AAI36487 DA192592 M90753 AAA59918 X64810 CAA46031 NM_000439 NP_000430 NM_001177875 NP_001171346 NM_001177876
Function Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin.
Subcellular Location Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules.

PC1/3 Antibody - 11914 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from mouse cortex, wild-type (WT) and PC1/3 (-/-) mouse hypothalamus, and human hypothalamus using PC1/3 Antibody (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). Tissues from WT and PC1/3 (-/-) mice were kindly provided by Dr. Robert Day (University of Sherbrooke, Quebec, Canada).

PCSK1 (D-13) - sc-163215 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PCSK1 (J-18) - sc-100578 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
PCSK1 (J-18): sc-100578. Western blot analysis of PCSK1 expression in HeLa whole cell lysate.

PCSK1 (S-14) - sc-163216 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PCSK1 (T-15) - sc-163217 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PC1/3 antibody - ab55543 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
PC1/3 antibody (ab55543) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human small Intestine.

Anti-PC1/3 antibody - ab191452 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed paraffin-embedded Rat Intestine tissue labeling PC1/3 with ab191452 at 1 µg/ml.

Anti-PC1/3 antibody - ab11786 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-PC1/3 antibody - ab28553 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PC1/3 antibody (ab28553) at 1/1000 dilutionLane 1 : Cell line SW 620. SFLane 2 : Cell line SW 620. TPALane 3 : Cell line SW 620. IL1-betaLysates/proteins at 0.05 µg per lane.

Anti-PC1/3 antibody - ab16020 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PC1/3 antibody [3D2] - ab117735 from Abcam

Prices $464.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3D2
Anti-PC1/3 antibody [3D2] (ab117735) + PC12 cell lysate

Anti-PC1/3 antibody - Aminoterminal end - ab28551 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PC1/3 antibody - Aminoterminal end (ab28551) at 1/1000 dilutionLane 1 : SF treated Hs1.Tes LysateLane 2 : TPA Hs1.Tes LysateLane 3 : IL1-beta Hs1.Tes LysateLane 4 : TNF-alpha Hs1.Tes LysateLane 5 : SF treated ST LysateLane 6 : TPA treated SF LysateLane 7 : IL1-beta ST LysateLysates/proteins at 10 µl per lane.

Anti-PC3 antibody - ab43678 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Polyclonal

Anti-PCSK1 Antibody - LS-C17371 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PCSK1 Antibody - LS-C42692 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PCSK1 Antibody (aa111-127) - LS-C89354 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PCSK1 Antibody (aa726-740) - LS-C313202 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
PCSK1 / PC1 antibody. IHC(P): Rat Intestine Tissue.

Anti-PCSK1 Antibody (aa683-732) IHC-plus™ - LS-B6536 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PCSK1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6536 concentration 5 ug/ml.

Anti-PCSK1 Antibody (clone 3D2) IHC-plus™ - LS-B5411 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3D2
Anti-PCSK1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5411 concentration 10 ug/ml.

PC1/3 Antibody (3D2) - H00005122-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3D2
Western Blot: PC1/3 Antibody (3D2) [H00005122-M02] - PCSK1 monoclonal antibody (M02), clone 3D2. Analysis of PCSK1 expression in Raw 264.7.

PC1/3 Antibody - NBP2-19714 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PC1/3 Antibody [NBP2-19714] - Sample (30 ug of whole cell lysate) A: HCT116 7. 5% SDS PAGE gel, diluted at 1:500.

PC1/3 Antibody - NBP2-13741 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: PC1/3 Antibody [NBP2-13741] Staining of human liver shows strong cytoplasmic positivity in hepatocytes.

PC1/3 Antibody - H00005122-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

PC1/3 Antibody (2G12) - H00005122-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2G12
Sandwich ELISA: PC1/3 Antibody (2G12) [H00005122-M01] - Detection limit for recombinant GST tagged PCSK1 is 0.03 ng/ml as a capture antibody.

Anti-PCSK1 (191-205) antibody produced in rabbit - SAB1100415 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-PCSK1 (191-205), <B>Cat. No. SAB1100415</B>: Immunofluorescence of HUVEC cells using Anti-PCSK1 (191-205), SAB1100415 (red), taken at 40× magnification and nuclear staining with Hoescht 33342 (blue). Yale HTCB IF procedure used. Images may have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com
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