Gene Symbol | PCSK1 |
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Entrez Gene | 5122 |
Alt Symbol | BMIQ12, NEC1, PC1, PC3, SPC3 |
Species | Human |
Gene Type | protein-coding |
Description | proprotein convertase subtilisin/kexin type 1 |
Other Description | neuroendocrine convertase 1|prohormone convertase 1|prohormone convertase 3 |
Swissprots | P78478 B7Z8T7 Q92532 E9PHA1 P29120 |
Accessions | AAA73788 BAA11133 EAW96062 EAW96063 P29120 AB208874 BAD92111 AK303888 BAH14073 AK308575 BC031211 BC130295 AAI30296 BC136486 AAI36487 DA192592 M90753 AAA59918 X64810 CAA46031 NM_000439 NP_000430 NM_001177875 NP_001171346 NM_001177876 |
Function | Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin. |
Subcellular Location | Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules. |
PCSK1 CRISPR/Cas9 KO Plasmid (h) - sc-404045 from Santa Cruz Biotechnology
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PCSK1 HDR Plasmid (h) - sc-404045-HDR from Santa Cruz Biotechnology
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PCSK1 Double Nickase Plasmid (h) - sc-404045-NIC from Santa Cruz Biotechnology
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PCSK1 Double Nickase Plasmid (h2) - sc-404045-NIC-2 from Santa Cruz Biotechnology
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PCSK1 CRISPR Activation Plasmid (h) - sc-404045-ACT from Santa Cruz Biotechnology
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PCSK1 CRISPR Activation Plasmid (h2) - sc-404045-ACT-2 from Santa Cruz Biotechnology
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PCSK1 Lentiviral Activation Particles (h) - sc-404045-LAC from Santa Cruz Biotechnology
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PCSK1 Lentiviral Activation Particles (h2) - sc-404045-LAC-2 from Santa Cruz Biotechnology
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PCSK1 siRNA (h) - sc-91918 from Santa Cruz Biotechnology
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PCSK1 shRNA Plasmid (h) - sc-91918-SH from Santa Cruz Biotechnology
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PCSK1 shRNA (h) Lentiviral Particles - sc-91918-V from Santa Cruz Biotechnology
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PC1/3 RNAi - H00005122-R01 from Novus Biologicals
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MISSION® esiRNA - EHU033661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16498 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16498 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11602 from Sigma-Aldrich
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PCSK1 siRNA (Human) - CRH3406 from Cohesion Biosciences
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shRNA set against Human PCSK1 (NM_000439.4) - SHH371996 from Creative biogene
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Human PCSK1 siRNA - orb263908 from Biorbyt
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PCSK1 shRNA Plasmid (Human) - CHH3406 from Cohesion Biosciences
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PCSK1 miRNA 3'UTR clone - MiUTR4H-TG06533 from Creative biogene
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