PRR5

Gene Symbol PRR5
Entrez Gene 55615
Alt Symbol FLJ20185k, PP610, PROTOR-1, PROTOR1
Species Human
Gene Type protein-coding
Description proline rich 5 (renal)
Other Description Rho GTPase activating protein 8|proline-rich protein 5|protein observed with Rictor-1
Swissprots Q96RW1 Q9UH20 Q9NXL1 Q5BIW2 Q9NVX8 B1AHG5 P85299 Q9NSG0 B3KP73 O95695 O75983 Q5XKJ6 Q9HC46 Q5EAJ8 B1AHF6 Q5EAJ9 Q9HA49 Q96RW2
Accessions EAW73353 EAW73354 EAW73357 P85299 AF177331 AAG17975 AK000192 BAA90999 AK055848 BAG51585 AK056787 AK091884 BAG52436 AK291564 BAF84253 AY859540 BC016921 AAH16921 BI825567 BK005635 DAA05654 BK005636 DAA05655 BK005637 DAA05656 BK005638 DAA05657 BK005639 DAA05658 BM682583 NM_001017528 NP_001017528 NM_001017529 NP_001017529 NM_001017530 NP_001017530 NM_001198721 NP_001185650 NM_015366 NP_056181 NM_181333 NP_851850
Function Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer. {ECO:0000269|PubMed:15718101, ECO:0000269|PubMed:17599906}.
Tissue Specificity Most abundant in kidney and liver. Also highly expressed in brain, spleen, testis and placenta. Overexpressed in several colorectal tumors. {ECO:0000269|PubMed:15718101, ECO:0000269|PubMed:17599906}.

PRR5 (A-7) - sc-390469 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PRR5 (A-7): sc-390469. Western blot analysis of PRR5 expression in non-transfected: sc-117752 (A) and human PRR5 transfected: sc-112138 (B) 293T whole cell lysates.

PRR5 (K-18) - sc-86803 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
PRR5 (K-18): sc-86803. Western blot analysis of PRR5 expression in non-transfected 293T: sc-117752 (A), human PRR5 transfected 293T: sc-112138 (B) and HeLa (C) whole cell lysates.

PRR5 (S-14) - sc-86804 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
PRR5 (S-14): sc-86804. Western blot analysis of PRR5 expression in MCF7 (A), SW480 (B), MDA-MB-231 (C), HeLa (D), HEK293 (E) and Hep G2 (F) whole cell lysates.

Anti-Protor-1 antibody - ab113269 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of Protor-1 in mouse brain tissue with ab113269 at 20 ug/mL.

Anti-Protor-1 antibody - ab133787 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed, paraffin-embedded Human kidney tissue labelling Protor-1 with ab133787 at 5 µg/ml. Primary incubation was followed by biotinylated Goat anti-Rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Protor-1 antibody - ab154684 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Protor-1 antibody (ab154684) at 1/1000 dilution + Raji whole cell lysate at 30 µg

Anti-Protor-1 antibody - ab80017 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Protor-1 antibody (ab80017) at 1 µg/mlLane 1 : Kidney (Human) Tissue Lysate - adult normal tissue (ab30203)Lane 2 : Liver (Human) Tissue Lysate - adult normal tissue (ab29889)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Protor-1 antibody - C-terminal - ab185995 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Protor-1 antibody - C-terminal (ab185995) at 0.1 µg/mlLane 1 : 293T whole cell lysateLane 2 : HeLa whole cell lysateLane 3 : Jurkat whole cell lysateLysates/proteins at 50 µg per lane.developed using the ECL technique

Anti-PRR5 Antibody (aa277-305) - LS-C158237 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Mouse Prr5 Antibody western blot of mouse spleen tissue lysates (35 ug/lane). The Prr5 antibody detected the Prr5 protein (arrow).

Anti-PRR5 Antibody (C-Terminus) IHC-plus™ - LS-B7098 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PRR5 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7098 concentration 5 ug/ml.

Anti-PRR5 Antibody (aa277-305, APC) - LS-C267214 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRR5 Antibody (aa277-305, AP) - LS-C267215 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRR5 Antibody (aa277-305, Biotin) - LS-C267216 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRR5 Antibody (aa277-305, Azide-free, HRP) - LS-C267218 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRR5 Antibody (aa277-305, PE) - LS-C267221 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRR5 Antibody (aa277-305, FITC) - LS-C267217 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRR5 Antibody (aa225-275) - LS-C290832 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PRR5 Antibody (aa277-305) - LS-C324327 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRR5 Antibody (aa35-84) - LS-C135404 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PRR5 antibody LS-C135404 Western blot of COLO205 cell lysate.

Anti-PRR5 Antibody (C-Terminus) - LS-C107853 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PRR5 antibody LS-C107853 Western blot of Fetal Brain lysate.

Anti-PRR5 Antibody (aa338-388) - LS-C290830 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Protor-1 by Western Blot. Samples: Whole cell lysate (50 ug) from 293T, HeLa, and Jurkat cells. Antibodies: Affinity purified rabbit anti-Protor-1 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

PRR5 Antibody - AF5309 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of HepG2 human hepatocellular carcinoma cell line, Jurkat human acute T cell leukemia cell line, and MCF‑7 human breast cancer cell line. PVDF membrane was probed with 1 µg/mL of Human PRR5 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5309) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). A specific band was detected for PRR5 at approximately 50 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 2.

PRR5 Antibody - NBP1-91481 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PRR5 Antibody [NBP1-91481] - COLO205 cells lysate, concentration 0.2-1 ug/ml.

PRR5L Antibody - NBP1-76568 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: PRR5L Antibody [NBP1-76568] - SK-N-SH cell lysate with PRR5 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide

PRR5 Antibody - NBP2-19968 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PRR5 Antibody [NBP2-19968] - Sample (30 ug of whole cell lysate) A: Raji 10% SDS PAGE gel, diluted at 1:1000.
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