| Gene Symbol |
PRR5
|
| Entrez Gene |
55615
|
| Alt Symbol |
FLJ20185k, PP610, PROTOR-1, PROTOR1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
proline rich 5 (renal)
|
| Other Description |
Rho GTPase activating protein 8|proline-rich protein 5|protein observed with Rictor-1
|
| Swissprots |
Q96RW1 Q9UH20 Q9NXL1 Q5BIW2 Q9NVX8 B1AHG5 P85299 Q9NSG0 B3KP73 O95695 O75983 Q5XKJ6 Q9HC46 Q5EAJ8 B1AHF6 Q5EAJ9 Q9HA49 Q96RW2
|
| Accessions |
EAW73353 EAW73354 EAW73357 P85299 AF177331 AAG17975 AK000192 BAA90999 AK055848 BAG51585 AK056787 AK091884 BAG52436 AK291564 BAF84253 AY859540 BC016921 AAH16921 BI825567 BK005635 DAA05654 BK005636 DAA05655 BK005637 DAA05656 BK005638 DAA05657 BK005639 DAA05658 BM682583 NM_001017528 NP_001017528 NM_001017529 NP_001017529 NM_001017530 NP_001017530 NM_001198721 NP_001185650 NM_015366 NP_056181 NM_181333 NP_851850
|
| Function |
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer. {ECO:0000269|PubMed:15718101, ECO:0000269|PubMed:17599906}.
|
| Tissue Specificity |
Most abundant in kidney and liver. Also highly expressed in brain, spleen, testis and placenta. Overexpressed in several colorectal tumors. {ECO:0000269|PubMed:15718101, ECO:0000269|PubMed:17599906}.
|
![Western Blot: PRR5 Overexpression Lysate (Adult Normal) [NBP2-10236] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PRR5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10317_PRR5%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10236-img0001.jpg)