PRR5

Gene Symbol	PRR5
Entrez Gene	55615
Alt Symbol	FLJ20185k, PP610, PROTOR-1, PROTOR1
Species	Human
Gene Type	protein-coding
Description	proline rich 5 (renal)
Other Description	Rho GTPase activating protein 8|proline-rich protein 5|protein observed with Rictor-1
Swissprots	Q96RW1 Q9UH20 Q9NXL1 Q5BIW2 Q9NVX8 B1AHG5 P85299 Q9NSG0 B3KP73 O95695 O75983 Q5XKJ6 Q9HC46 Q5EAJ8 B1AHF6 Q5EAJ9 Q9HA49 Q96RW2
Accessions	EAW73353 EAW73354 EAW73357 P85299 AF177331 AAG17975 AK000192 BAA90999 AK055848 BAG51585 AK056787 AK091884 BAG52436 AK291564 BAF84253 AY859540 BC016921 AAH16921 BI825567 BK005635 DAA05654 BK005636 DAA05655 BK005637 DAA05656 BK005638 DAA05657 BK005639 DAA05658 BM682583 NM_001017528 NP_001017528 NM_001017529 NP_001017529 NM_001017530 NP_001017530 NM_001198721 NP_001185650 NM_015366 NP_056181 NM_181333 NP_851850
Function	Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer. {ECO:0000269|PubMed:15718101, ECO:0000269|PubMed:17599906}.
Tissue Specificity	Most abundant in kidney and liver. Also highly expressed in brain, spleen, testis and placenta. Overexpressed in several colorectal tumors. {ECO:0000269|PubMed:15718101, ECO:0000269|PubMed:17599906}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PRR5 gene - orb91649 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human-PRR5-cDNA-Clone - DC04383 from Abgent, a WuXi AppTec company Prices $387.45 Sizes 10 µg Species Human Accession BC016921

PRR5 - MBS1275080 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC016921

Human PRR5 cDNA clone(NM_001017530.1) - CDFH015251 from Creative Biomart Species Human Accession NM_001017530.1

Human PRR5 ORF Clone(NM_001017528.2) - CDCL172773 from Creative Biomart Species Human Accession NM_001017528.2

Human PRR5 ORF Clone(NM_001017530.1) - CDCR341876 from Creative Biomart Species Human Accession NM_001017530.1

Human PRR5 ORF Clone(NM_001017530.1) - CDCR341877 from Creative Biomart Species Human Accession NM_001017530.1

Human PRR5 ORF Clone(NM_001198721.1) - CDCR358944 from Creative Biomart Species Human Accession NM_001198721.1

Human PRR5 ORF Clone(NM_001198721.1) - CDCR358945 from Creative Biomart Species Human Accession NM_001198721.1

Human PRR5 transcript variant 1 Gene ORF cDNA clone in cloning vector - HG11155-M from Sino Biological Species Human

Human PRR5 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11155-CY from Sino Biological Species Human

Human PRR5 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11155-ACR from Sino Biological Species Human

Human PRR5 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11155-ANR from Sino Biological Species Human

Human PRR5 transcript variant 1 Gene ORF cDNA clone expression plasmid - HG11155-UT from Sino Biological Species Human

Human PRR5 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11155-ACG from Sino Biological Species Human

Human PRR5 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11155-NY from Sino Biological Species Human

Human PRR5 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11155-NF from Sino Biological Species Human

Human PRR5 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-His tag - HG11155-NH from Sino Biological Species Human

Human PRR5 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11155-NM from Sino Biological Species Human

Human PRR5 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11155-M-F from Sino Biological Species Human

Human PRR5 transcript variant 1 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG11155-M-N from Sino Biological Species Human Accession NM_181333.2

Human PRR5 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11155-ANG from Sino Biological Species Human

Human PRR5 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11155-CF from Sino Biological Species Human

Human PRR5 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-His tag - HG11155-CH from Sino Biological Species Human

Human PRR5 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11155-CM from Sino Biological Species Human

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