PRR5

Gene Symbol PRR5
Entrez Gene 55615
Alt Symbol FLJ20185k, PP610, PROTOR-1, PROTOR1
Species Human
Gene Type protein-coding
Description proline rich 5 (renal)
Other Description Rho GTPase activating protein 8|proline-rich protein 5|protein observed with Rictor-1
Swissprots Q96RW1 Q9UH20 Q9NXL1 Q5BIW2 Q9NVX8 B1AHG5 P85299 Q9NSG0 B3KP73 O95695 O75983 Q5XKJ6 Q9HC46 Q5EAJ8 B1AHF6 Q5EAJ9 Q9HA49 Q96RW2
Accessions EAW73353 EAW73354 EAW73357 P85299 AF177331 AAG17975 AK000192 BAA90999 AK055848 BAG51585 AK056787 AK091884 BAG52436 AK291564 BAF84253 AY859540 BC016921 AAH16921 BI825567 BK005635 DAA05654 BK005636 DAA05655 BK005637 DAA05656 BK005638 DAA05657 BK005639 DAA05658 BM682583 NM_001017528 NP_001017528 NM_001017529 NP_001017529 NM_001017530 NP_001017530 NM_001198721 NP_001185650 NM_015366 NP_056181 NM_181333 NP_851850
Function Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer. {ECO:0000269|PubMed:15718101, ECO:0000269|PubMed:17599906}.
Tissue Specificity Most abundant in kidney and liver. Also highly expressed in brain, spleen, testis and placenta. Overexpressed in several colorectal tumors. {ECO:0000269|PubMed:15718101, ECO:0000269|PubMed:17599906}.

Human Protor-1 peptide - ab89386 from Abcam

Category Peptide

PRR5 Antibody Blocking Peptide - LS-E20651 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

PRR5 Antibody Blocking Peptide - LS-E20652 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

PRR5 Antibody Blocking Peptide - LS-E6567 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

PRR5 Antibody Blocking Peptide - LS-E31110 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 50 µg

PRR5 Blocking Peptide - 33R-6877 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

PRR5 Blocking Peptide - 33R-3387 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

PRR5 control peptide - AP26126CP-N from Acris Antibodies

Category Peptide
Prices $135.00
Sizes 50 µg
Western blot analysis of PRR5 in SK-N-SH cell lysate with PRR5 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide

PRR5 Peptide - 6291P from ProSci

Category Peptide
Species Human
Western blot analysis of PRR5 in SK-N-SH cell lysate with PRR5 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.

PRR5 fusion protein - ag12296 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human
PRR5 fusion protein ag12296 SDS-PAGE

PRR5 fusion protein - ag12424 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human PRR5, His-tagged - PRR5-1988H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Human Proline-rich protein 5(PRR5) - CSB-YP018796HU CSB-EP018796HU CSB-BP018796HU CSB-MP018796HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

PRR5 (transcript variant 2) - TP317823 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
PRR5

Proline-rich protein 5 (PRR5), Recombinant Protein - MBS966955 from MyBioSource

Category Protein
Prices $1,160.00, $1,160.00, $1,390.00, $1,390.00, $1,855.00, $1,855.00, $2,315.00, $2,315.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

PTOR1-Antibody-C-term-Blocking-Peptide - BP4875b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

PRR5 Peptide, Human - M34GP12498H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human
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