Gene Symbol | FRS3 |
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Entrez Gene | 10817 |
Alt Symbol | FRS2-beta, FRS2B, FRS2beta, SNT-2, SNT2 |
Species | Human |
Gene Type | protein-coding |
Description | fibroblast growth factor receptor substrate 3 |
Other Description | FGFR substrate 3|FGFR-signaling adaptor SNT2|suc1-associated neurotrophic factor target 2 (FGFR signalling adaptor) |
Swissprots | O43559 Q5T3D5 |
Accessions | EAX04060 O43559 AF036718 AAB92555 BC010611 AAH10611 BM741175 CR457026 CAG33307 DQ892075 ABM83001 DQ895268 ABM86194 HY036161 XM_011514254 XP_011512556 XM_011514255 XP_011512557 NM_006653 NP_006644 |
Function | Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2. {ECO:0000269|PubMed:15094036}. |
Subcellular Location | Membrane; Lipid-anchor. |
FRS3 CRISPR/Cas9 KO Plasmid (h) - sc-411519 from Santa Cruz Biotechnology
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FRS3 HDR Plasmid (h) - sc-411519-HDR from Santa Cruz Biotechnology
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FRS3 Double Nickase Plasmid (h) - sc-411519-NIC from Santa Cruz Biotechnology
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FRS3 Double Nickase Plasmid (h2) - sc-411519-NIC-2 from Santa Cruz Biotechnology
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FRS3 CRISPR Activation Plasmid (h) - sc-411519-ACT from Santa Cruz Biotechnology
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FRS3 CRISPR Activation Plasmid (h2) - sc-411519-ACT-2 from Santa Cruz Biotechnology
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FRS3 Lentiviral Activation Particles (h) - sc-411519-LAC from Santa Cruz Biotechnology
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FRS3 Lentiviral Activation Particles (h2) - sc-411519-LAC-2 from Santa Cruz Biotechnology
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FRS3 siRNA (h) - sc-95637 from Santa Cruz Biotechnology
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FRS3 shRNA Plasmid (h) - sc-95637-SH from Santa Cruz Biotechnology
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FRS3 shRNA (h) Lentiviral Particles - sc-95637-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU021821 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8956 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8956 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03336 from Sigma-Aldrich
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FRS3 siRNA (Human) - CRH7375 from Cohesion Biosciences
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FRS3 RNAi - H00010817-R02 from Novus Biologicals
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FRS3 - MBS8235094 from MyBioSource
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shRNA set against Human FRS3 (NM_006653.3) - SHH297257 from Creative biogene
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shRNA set against Human FRS3(NM_006653.3) - SHH068537 from Creative biogene
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Human FRS3 siRNA - orb267877 from Biorbyt
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FRS3 shRNA Plasmid (Human) - CHH7375 from Cohesion Biosciences
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FRS3 miRNA 3'UTR clone - MiUTR1H-03855 from Creative biogene
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