| Gene Symbol |
PTGER4
|
| Entrez Gene |
5734
|
| Alt Symbol |
EP4, EP4R
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
prostaglandin E receptor 4 (subtype EP4)
|
| Other Description |
PGE receptor EP4 subtype|PGE receptor, EP4 subtype|PGE2 receptor EP4 subtype|prostaglandin E2 receptor EP4 subtype|prostanoid EP4 receptor
|
| Swissprots |
P35408 Q3MJ87
|
| Accessions |
ABD48960 CAA66463 CCF76996 EAW55996 EAW55997 P35408 AY429109 AAR07904 BC027934 AAH27934 BC101534 AAI01535 BC113523 AAI13524 BM312677 BQ029720 CD000197 D28472 BAA05834 HQ258444 ADR83198 L25124 AAA36438 L28175 AAA36434 XM_005248326 XP_005248383 XM_005248327 XP_005248384 XM_011514070 XP_011512372 XM_011514071 XP_011512373 XR_925635 NM_000958 NP_000949
|
| Function |
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle.
|
| Top Pathways |
Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction
|