| Gene Symbol |
NOTO
|
| Entrez Gene |
344022
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
notochord homeobox
|
| Other Description |
homeobox protein notochord|notochord homolog
|
| Swissprots |
A8MTQ0 B4DJ59 B7ZAU5
|
| Accessions |
A8MTQ0 AK295936 BAG58721 AK316410 BAH14781 NM_001134462 NP_001127934
|
| Function |
Transcription regulator acting downstream of both FOXA2 and T during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}.
|
![Western Blot: NOTO Overexpression Lysate (Adult Normal) [NBP2-09547] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NOTO.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6467_NOTO%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-09547-img0001.jpg)