Gene Symbol | NOTO |
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Entrez Gene | 344022 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | notochord homeobox |
Other Description | homeobox protein notochord|notochord homolog |
Swissprots | A8MTQ0 B4DJ59 B7ZAU5 |
Accessions | A8MTQ0 AK295936 BAG58721 AK316410 BAH14781 NM_001134462 NP_001127934 |
Function | Transcription regulator acting downstream of both FOXA2 and T during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}. |
NOTO CRISPR/Cas9 KO Plasmid (h) - sc-407887 from Santa Cruz Biotechnology
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NOTO HDR Plasmid (h) - sc-407887-HDR from Santa Cruz Biotechnology
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NOTO Double Nickase Plasmid (h) - sc-407887-NIC from Santa Cruz Biotechnology
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NOTO Double Nickase Plasmid (h2) - sc-407887-NIC-2 from Santa Cruz Biotechnology
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NOTO CRISPR Activation Plasmid (h) - sc-407887-ACT from Santa Cruz Biotechnology
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NOTO CRISPR Activation Plasmid (h2) - sc-407887-ACT-2 from Santa Cruz Biotechnology
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NOTO Lentiviral Activation Particles (h) - sc-407887-LAC from Santa Cruz Biotechnology
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NOTO Lentiviral Activation Particles (h2) - sc-407887-LAC-2 from Santa Cruz Biotechnology
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NOTO siRNA (h) - sc-94333 from Santa Cruz Biotechnology
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NOTO shRNA Plasmid (h) - sc-94333-SH from Santa Cruz Biotechnology
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NOTO shRNA (h) Lentiviral Particles - sc-94333-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN15423 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15423 from Sigma-Aldrich
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NOTO siRNA (Human) - CRJ7443 from Cohesion Biosciences
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Human NOTO siRNA - orb277944 from Biorbyt
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NOTO shRNA Plasmid (Human) - CHJ7443 from Cohesion Biosciences
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