| Gene Symbol |
VIMP
|
| Entrez Gene |
55829
|
| Alt Symbol |
AD-015, ADO15, SBBI8, SELS, SEPS1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
VCP-interacting membrane protein
|
| Other Description |
selenoprotein S
|
| Swissprots |
Q3B771 Q9P0I6 Q9BQE4
|
| Accessions |
EAX02295 Q9BQE4 AA487772 AF157317 AAF67483 AF328864 AAK15708 AI673590 AK026455 AK097011 AK225955 AK314723 AY324824 AAP85541 AY618665 AAT46592 BC005840 AAH05840 BC107774 AAI07775 BG829960 BI494034 BQ014190 BU740863 DQ578816 DW430970 NM_018445 NP_060915 NM_203472 NP_982298
|
| Function |
Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination. {ECO:0000269|PubMed:15215856}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Single-pass membrane protein. Cytoplasm {ECO:0000250}.
|
| Top Pathways |
Protein processing in endoplasmic reticulum
|