KIAA0196

Gene Symbol KIAA0196
Entrez Gene 9897
Alt Symbol RTSC, SPG8
Species Human
Gene Type protein-coding
Description KIAA0196
Other Description WASH complex subunit strumpellin|strumpellin
Swissprots Q8TBQ2 A8K4R7 Q12768 Q3KQX5
Accessions EAW92080 EAW92081 EAW92082 Q12768 AI266595 AK223628 BAD97348 AK291032 BAF83721 AK296970 BAG59514 BC026951 AAH26951 BC106015 AAI06016 D83780 BAA12109 DA185885 XM_005251120 XP_005251177 XM_011517409 XP_011515711 XM_011517410 XP_011515712 NM_014846 NP_055661
Function Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093). May be involved in axonal outgrowth. Involved in cellular localization of ADRB2 (PubMed:23085491). Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 (PubMed:23676666). {ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20833645, ECO:0000269|PubMed:23085491, ECO:0000269|PubMed:23676666}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:20833645}. Endoplasmic reticulum {ECO:0000269|PubMed:20833645}. Early endosome {ECO:0000269|PubMed:23085491, ECO:0000269|PubMed:23676666}. Note=Colocalizes with SYP/synaptophysin in the external molecular layer of the dentate gyrus and in motoneurons of the ventral horn of spinal cord. {ECO:0000269|PubMed:20833645}.
Tissue Specificity Expressed ubiquitously. {ECO:0000269|PubMed:20833645}.

Strumpellin (B-10) - sc-377146 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Strumpellin (B-10): sc-377146. Western blot analysis of Strumpellin expression in DU 145 (A) and Ramos (B) whole cell lysates.

Strumpellin (P-16) - sc-87444 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Strumpellin (P-16): sc-87444. Western blot analysis of Strumpellin expression in DU 145 whole cell lysate.

Strumpellin (H-300) - sc-134888 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Strumpellin (C-14) - sc-87442 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Strumpellin (C-14): sc-87442. Western blot analysis of Strumpellin expression in HeLa (A), Ramos (B), Hep G2 (C) and DU 145 (D) whole cell lysates.

Anti-Strumpellin antibody - ab101222 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Strumpellin antibody (ab101222) at 1 µg/mlLane 1 : Brain (Mouse) Tissue LysateLane 2 : Spinal Cord (Mouse) Tissue LysateLane 3 : Lung (Mouse) Whole Cell Lysate - normal tissue (ab29297)Lane 4 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 5 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Strumpellin antibody - ab126109 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Strumpellin antibody (ab126109) at 1/500 dilution + HeLa cell lysate at 30 µg

Anti-KIAA0196 Antibody (Internal) - LS-C145183 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KIAA0196 Antibody (C-Terminus) - LS-C155404 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded Gastric ca, using KIAA0196 antibody at 1:500 dilution.

Anti-KIAA0196 Antibody (C-Terminus) - LS-C144426 from LifeSpan Bioscience

Prices $325.00, $890.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of Strumpellin in human ovary tissue lysate with Strumpellin antibody at 1 ug/ml.

SPG8 Antibody - NBP2-20471 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SPG8 Antibody [NBP2-20471] - Sample (30 ug of whole cell lysate) A: HeLa 5% SDS PAGE gel, diluted at 1:500.

SPG8 Antibody - 45530002 from Novus Biologicals

Prices $299.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ELISA: SPG8 Antibody [45530002]

Anti-Strumpellin antibody produced in rabbit - SAB4200549 from Sigma-Aldrich

Prices $337.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell line lysates were separated on SDS-PAGE and probed with 5 μg/mL Rabbit Anti-Stumpellin (<B>Cat. No. SAB4200549</B>). The antibody was developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate.<BR/><B>Lanes</B><BR/>1. Du-145<BR/>2. A-20 <BR/>3. A-10<BR/>4. PC-3<BR/>5. HeLa<BR/>6. HepG2<BR/>7. JURKAT<BR/>8. 3T3<BR/>9. T47D

Anti-Strumpellin (C-terminal) antibody produced in rabbit - SAB4200550 from Sigma-Aldrich

Prices $337.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell line lysates were separated on SDS-PAGE and probed with 5 μg/mL Rabbit Anti-Strumpellin (C-terminal) (<B>Cat. No. SAB4200550</B>). The antibody was developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate.<BR/><B>Lanes</B><BR/>1. PC-3<BR/>2. HeLa<BR/>3. HepG2

Anti-KIAA0196 (C-terminal) antibody produced in rabbit - SAB2700097 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-KIAA0196 (C-terminal): <B>Cat. No. SAB2700097</B>: Immunohistochemical analysis of paraffin-embedded Gastric carcinoma, using KIAA0196 antibody at 1:100 dilution.

Anti-KIAA0196 antibody produced in rabbit - SAB3500640 from Sigma-Aldrich

Prices $341.00
Sizes 100 µg
Host Rabbit
<B>Immunoblotting</B><BR/>Anti-KIAA0196; <B>Cat. No. SAB3500640</B>; Western blot analysis of Strumpellin in Human ovary tissue lysate with Strumpellin antibody at 1 μ/mL.

KIAA0196 antibody [C2C3], C-term - GTX115311 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-KIAA0196 antibody [C2C3], C-term used in IHC (Formalin-fixed paraffin-embedded sections). GTX115311

Strumpellin antibody - orb75667 from Biorbyt

Prices $723.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Western blot analysis of human ovary tissue lysate at 1 ug/mL using Strumpellin antibody

Strumpellin (C-term) antibody - AP55590PU-N from Acris Antibodies

Prices $340.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of Strumpellin in human ovary tissue lysate with Strumpellin antibody Cat.-No AP55590PU-N at 1 μg/ml.

Strumpellin Antibody - 6497 from ProSci

Prices $79.00, $325.00
Sizes 20 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of Strumpellin in human ovary tissue lysate with Strumpellin antibody at 1 μg/mL.

Strumpellin Antibody - 25361 from Signalway Antibody

Prices $390.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of Strumpellin in human ovary tissue lysate with Strumpellin antibody at 1 ug/mL.

KIAA0196 - MBS276900 from MyBioSource

Prices $360.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: HeLa 5% SDS PAGE diluted at 1:500

Anti-KIAA0196 (aa 938-1112) polyclonal antibody - DPABH-22513 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-KIAA0196 (C-terminal) polyclonal antibody - DPAB-L20640 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

SPG8/Strumpellin Antibody - A304-809A from Bethyl Labs

Prices $99.00, $229.00, $339.00
Sizes 20 µl (2 blots), 100 µl (10 blots), 100 µl (1 mg/ml)
Host Rabbit
Clonality Polyclonal

KIAA0196 Polyclonal Antibody - PA5-30337 from Thermo Fisher Scientific

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of KIAA0196 in paraffin-embedded gastric carcinoma using a KIAA0196 polyclonal antibody (Product # PA5-30337) at a dilution of 1:500.
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