| Gene Symbol |
PES1
|
| Entrez Gene |
23481
|
| Alt Symbol |
PES
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pescadillo ribosomal biogenesis factor 1
|
| Other Description |
pescadillo homolog|pescadillo homolog 1, containing BRCT domain
|
| Swissprots |
Q6IC29 O00541
|
| Accessions |
EAW59904 EAW59905 EAW59906 O00541 AB451380 BAG70194 AK096320 BAG53258 AK125778 BAC86285 AK127185 BAG54448 AK315518 BAG37899 AU098520 AU130886 BC032489 AAH32489 BQ576244 CR456539 CAG30425 CU013139 CAK54570 CU013427 CAK54869 U78310 AAB61140 XM_006724173 XP_006724236 NM_001243225 NP_001230154 NM_001282327 NP_001269256 NM_001282328 NP_001269257 NM_014303 NP_055118
|
| Function |
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03028, ECO:0000269|PubMed:16738141, ECO:0000269|PubMed:17189298, ECO:0000269|PubMed:17353269}.
|
| Subcellular Location |
Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli. {ECO:0000255|HAMAP-Rule:MF_03028}.
|
| Tissue Specificity |
Significant levels are detected in a variety of cancer cell lines, including glioblastoma, breast carcinoma, colon carcinoma and cervical carcinoma cells. Levels are abnormally elevated in malignant tumors of astrocytic origin.
|
