Gene Symbol | PES1 |
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Entrez Gene | 23481 |
Alt Symbol | PES |
Species | Human |
Gene Type | protein-coding |
Description | pescadillo ribosomal biogenesis factor 1 |
Other Description | pescadillo homolog|pescadillo homolog 1, containing BRCT domain |
Swissprots | Q6IC29 O00541 |
Accessions | EAW59904 EAW59905 EAW59906 O00541 AB451380 BAG70194 AK096320 BAG53258 AK125778 BAC86285 AK127185 BAG54448 AK315518 BAG37899 AU098520 AU130886 BC032489 AAH32489 BQ576244 CR456539 CAG30425 CU013139 CAK54570 CU013427 CAK54869 U78310 AAB61140 XM_006724173 XP_006724236 NM_001243225 NP_001230154 NM_001282327 NP_001269256 NM_001282328 NP_001269257 NM_014303 NP_055118 |
Function | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03028, ECO:0000269|PubMed:16738141, ECO:0000269|PubMed:17189298, ECO:0000269|PubMed:17353269}. |
Subcellular Location | Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli. {ECO:0000255|HAMAP-Rule:MF_03028}. |
Tissue Specificity | Significant levels are detected in a variety of cancer cell lines, including glioblastoma, breast carcinoma, colon carcinoma and cervical carcinoma cells. Levels are abnormally elevated in malignant tumors of astrocytic origin. |
pescadillo CRISPR/Cas9 KO Plasmid (h) - sc-418006 from Santa Cruz Biotechnology
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pescadillo HDR Plasmid (h) - sc-418006-HDR from Santa Cruz Biotechnology
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pescadillo Double Nickase Plasmid (h) - sc-418006-NIC from Santa Cruz Biotechnology
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pescadillo Double Nickase Plasmid (h2) - sc-418006-NIC-2 from Santa Cruz Biotechnology
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pescadillo CRISPR Activation Plasmid (h) - sc-418006-ACT from Santa Cruz Biotechnology
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pescadillo CRISPR Activation Plasmid (h2) - sc-418006-ACT-2 from Santa Cruz Biotechnology
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pescadillo Lentiviral Activation Particles (h) - sc-418006-LAC from Santa Cruz Biotechnology
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pescadillo Lentiviral Activation Particles (h2) - sc-418006-LAC-2 from Santa Cruz Biotechnology
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pescadillo siRNA (h) - sc-61328 from Santa Cruz Biotechnology
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pescadillo shRNA Plasmid (h) - sc-61328-SH from Santa Cruz Biotechnology
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pescadillo shRNA (h) Lentiviral Particles - sc-61328-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU085051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16626 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16626 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03248 from Sigma-Aldrich
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PES1 siRNA (Human) - CRH8299 from Cohesion Biosciences
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shRNA set against Human PES1 (NM_014303.3) - SHH373588 from Creative biogene
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PES1 shRNA Plasmid (Human) - CHH8299 from Cohesion Biosciences
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PES1 miRNA 3'UTR clone - MiUTR3H-07985 from Creative biogene
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