CD55
| Gene Symbol | CD55 |
|---|---|
| Entrez Gene | 1604 |
| Alt Symbol | CR, CROM, DAF, TC |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD55 molecule, decay accelerating factor for complement (Cromer blood group) |
| Other Description | CD55 antigen|complement decay-accelerating factor |
| Swissprots | D3DT84 P78361 Q14UF3 B1AP14 P09679 Q14UF4 D3DT83 Q14UF2 Q14UF5 E7ER69 Q14UF6 P08174 |
| Accessions | AAA52170 AAC60633 AAW29942 BAA22900 CBX47421 EAW93485 EAW93486 EAW93487 EAW93488 EAW93489 EAW93490 EAW93491 EAW93492 EAW93493 EAW93494 EAW93495 EAW93496 EAW93497 EAW93498 EAW93499 P08174 AB240566 BAE97422 AB240567 BAE97423 AB240568 BAE97424 AB240569 BAE97425 AB240570 BAE97426 AF052110 AK298549 BAG60746 AK300621 BAG62314 AK312448 BAG35355 AW316643 AY055757 AAL25832 AY055758 AAL25833 AY055759 AAL25834 AY055760 AAL25835 BC001288 AAH01288 BI545505 BT007159 AAP35823 CA432400 CA748776 DC386415 DQ890776 ABM81702 DQ893935 ABM84861 M15799 AAA52167 M30142 AAA52168 M31516 AAA52169 S70688 AAB20576 U88576 AAB48622 NM_000574 NP_000565 NM_001114752 NP_001108224 NM_001300902 NP_001287831 NM_001300903 NP_001287832 NM_001300904 NP_001287833 NR_125349 NM_001114543 NM_001114544 |
| Function | This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. {ECO:0000269|PubMed:7525274}. |
| Subcellular Location | Isoform 7: Cell membrane {ECO:0000305|PubMed:16503113}; Lipid-anchor, GPI-anchor {ECO:0000305|PubMed:16503113}. |
| Tissue Specificity | Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix. |
| Top Pathways | Complement and coagulation cascades, Hematopoietic cell lineage |
CD55 CRISPR/Cas9 KO Plasmid (h) - sc-400738 from Santa Cruz Biotechnology
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CD55 HDR Plasmid (h) - sc-400738-HDR from Santa Cruz Biotechnology
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CD55 Double Nickase Plasmid (h) - sc-400738-NIC from Santa Cruz Biotechnology
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CD55 Double Nickase Plasmid (h2) - sc-400738-NIC-2 from Santa Cruz Biotechnology
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CD55 CRISPR Activation Plasmid (h) - sc-400738-ACT from Santa Cruz Biotechnology
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CD55 CRISPR Activation Plasmid (h2) - sc-400738-ACT-2 from Santa Cruz Biotechnology
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CD55 Lentiviral Activation Particles (h) - sc-400738-LAC from Santa Cruz Biotechnology
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CD55 Lentiviral Activation Particles (h2) - sc-400738-LAC-2 from Santa Cruz Biotechnology
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CD55 siRNA (h) - sc-35012 from Santa Cruz Biotechnology
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CD55 shRNA Plasmid (h) - sc-35012-SH from Santa Cruz Biotechnology
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CD55 shRNA (h) Lentiviral Particles - sc-35012-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU080491 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5738 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5738 from Sigma-Aldrich
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CD55 siRNA (Human) - CRH1127 from Cohesion Biosciences
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CD55/DAF RNAi - H00001604-R01 from Novus Biologicals
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CD55 - MBS8211046 from MyBioSource
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shRNA set against Human CD55 (NM_000574.3) - SHH259209 from Creative biogene
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shRNA set against Human CD55(NM_000574.3) - SHG158041 from Creative biogene
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CD55 shRNA Plasmid (Human) - CHH1127 from Cohesion Biosciences
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CD55 miRNA 3'UTR clone - MiUTR1H-01891 from Creative biogene
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CD55 miRNA 3'UTR clone - MiUTR3H-00634 from Creative biogene
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