FCHO1

Gene Symbol FCHO1
Entrez Gene 23149
Alt Symbol -
Species Human
Gene Type protein-coding
Description FCH domain only 1
Other Description F-BAR domain only protein 1|FCH domain only protein 1
Swissprots A6NHE6 Q05C93 Q8IW22 B4E120 O14526 A8K5U5
Accessions CAD35013 EAW84628 EAW84629 EAW84630 O14526 AB006628 BAA22959 AK291410 BAF84099 AK303623 BAG64632 AK309403 AK316458 BAH14829 BC028021 AAH28021 BC041130 AAH41130 BI756664 BQ433639 DB158605 XM_005259831 XP_005259888 XM_006722701 XP_006722764 XM_006722702 XP_006722765 XM_011527824 XP_011526126 XM_011527825 XP_011526127 XM_011527826 XP_011526128 XM_011527827 XP_011526129 XM_011527828 XP_011526130 NM_001161357 NP_001154829 NM_001161358 NP_001154830 NM_001161359 NP_001154831 NM_015122 NP_055937
Function Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. {ECO:0000269|PubMed:20448150}.
Subcellular Location Membrane, clathrin-coated pit {ECO:0000305|PubMed:17617719, ECO:0000305|PubMed:20448150}; Peripheral membrane protein {ECO:0000305|PubMed:17617719, ECO:0000305|PubMed:20448150}; Cytoplasmic side {ECO:0000305|PubMed:17617719, ECO:0000305|PubMed:20448150}. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2. According to PubMed:17617719 it may also dynamically associate with Golgi/TGN membranes.

Panoply™ Human FCHO1 Knockdown Stable Cell Line - CSC-DC005644 from Creative biogene

Category Cell Line
Species Human
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