| Gene Symbol | FCHO1 |
|---|---|
| Entrez Gene | 23149 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | FCH domain only 1 |
| Other Description | F-BAR domain only protein 1|FCH domain only protein 1 |
| Swissprots | A6NHE6 Q05C93 Q8IW22 B4E120 O14526 A8K5U5 |
| Accessions | CAD35013 EAW84628 EAW84629 EAW84630 O14526 AB006628 BAA22959 AK291410 BAF84099 AK303623 BAG64632 AK309403 AK316458 BAH14829 BC028021 AAH28021 BC041130 AAH41130 BI756664 BQ433639 DB158605 XM_005259831 XP_005259888 XM_006722701 XP_006722764 XM_006722702 XP_006722765 XM_011527824 XP_011526126 XM_011527825 XP_011526127 XM_011527826 XP_011526128 XM_011527827 XP_011526129 XM_011527828 XP_011526130 NM_001161357 NP_001154829 NM_001161358 NP_001154830 NM_001161359 NP_001154831 NM_015122 NP_055937 |
| Function | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. {ECO:0000269|PubMed:20448150}. |
| Subcellular Location | Membrane, clathrin-coated pit {ECO:0000305|PubMed:17617719, ECO:0000305|PubMed:20448150}; Peripheral membrane protein {ECO:0000305|PubMed:17617719, ECO:0000305|PubMed:20448150}; Cytoplasmic side {ECO:0000305|PubMed:17617719, ECO:0000305|PubMed:20448150}. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2. According to PubMed:17617719 it may also dynamically associate with Golgi/TGN membranes. |
FCHO1 CRISPR/Cas9 KO Plasmid (h) - sc-406171 from Santa Cruz Biotechnology
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FCHO1 HDR Plasmid (h) - sc-406171-HDR from Santa Cruz Biotechnology
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FCHO1 Double Nickase Plasmid (h) - sc-406171-NIC from Santa Cruz Biotechnology
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FCHO1 Double Nickase Plasmid (h2) - sc-406171-NIC-2 from Santa Cruz Biotechnology
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FCHO1 CRISPR Activation Plasmid (h) - sc-406171-ACT from Santa Cruz Biotechnology
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FCHO1 CRISPR Activation Plasmid (h2) - sc-406171-ACT-2 from Santa Cruz Biotechnology
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FCHO1 Lentiviral Activation Particles (h) - sc-406171-LAC from Santa Cruz Biotechnology
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FCHO1 Lentiviral Activation Particles (h2) - sc-406171-LAC-2 from Santa Cruz Biotechnology
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FCHO1 siRNA (h) - sc-97726 from Santa Cruz Biotechnology
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FCHO1 shRNA Plasmid (h) - sc-97726-SH from Santa Cruz Biotechnology
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FCHO1 shRNA (h) Lentiviral Particles - sc-97726-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU028661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8595 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8595 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01028 from Sigma-Aldrich
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FCHO1 siRNA (Human) - CRH8035 from Cohesion Biosciences
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FCHO1 - MBS8238934 from MyBioSource
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FCHO1 CRISPR/Cas9 KO Plasmid (h2) - sc-406171-KO-2 from Santa Cruz Biotechnology
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FCHO1 HDR Plasmid (h2) - sc-406171-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human FCHO1 (NM_015122.2) - SHH293773 from Creative biogene
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Human FCHO1 siRNA - orb268537 from Biorbyt
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FCHO1 shRNA Plasmid (Human) - CHH8035 from Cohesion Biosciences
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FCHO1 miRNA 3'UTR clone - MiUTR3H-12893 from Creative biogene
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FCHO1 miRNA 3'UTR clone - MiUTR3H-12894 from Creative biogene
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FCHO1 miRNA 3'UTR clone - MiUTR3H-12895 from Creative biogene
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