| Gene Symbol |
FCHO1
|
| Entrez Gene |
23149
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
FCH domain only 1
|
| Other Description |
F-BAR domain only protein 1|FCH domain only protein 1
|
| Swissprots |
A6NHE6 Q05C93 Q8IW22 B4E120 O14526 A8K5U5
|
| Accessions |
CAD35013 EAW84628 EAW84629 EAW84630 O14526 AB006628 BAA22959 AK291410 BAF84099 AK303623 BAG64632 AK309403 AK316458 BAH14829 BC028021 AAH28021 BC041130 AAH41130 BI756664 BQ433639 DB158605 XM_005259831 XP_005259888 XM_006722701 XP_006722764 XM_006722702 XP_006722765 XM_011527824 XP_011526126 XM_011527825 XP_011526127 XM_011527826 XP_011526128 XM_011527827 XP_011526129 XM_011527828 XP_011526130 NM_001161357 NP_001154829 NM_001161358 NP_001154830 NM_001161359 NP_001154831 NM_015122 NP_055937
|
| Function |
Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. {ECO:0000269|PubMed:20448150}.
|
| Subcellular Location |
Membrane, clathrin-coated pit {ECO:0000305|PubMed:17617719, ECO:0000305|PubMed:20448150}; Peripheral membrane protein {ECO:0000305|PubMed:17617719, ECO:0000305|PubMed:20448150}; Cytoplasmic side {ECO:0000305|PubMed:17617719, ECO:0000305|PubMed:20448150}. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2. According to PubMed:17617719 it may also dynamically associate with Golgi/TGN membranes.
|