| Gene Symbol |
PRKG1
|
| Entrez Gene |
5592
|
| Alt Symbol |
1, AAT8, PKG, PRKG1B, PRKGR1B, cGK, cGK 1, cGK1, cGKI, cGKI-BETA, cGKI-alpha
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein kinase, cGMP-dependent, type I
|
| Other Description |
cGMP-dependent protein kinase 1|protein kinase, cGMP-dependent, regulatory, type I, beta
|
| Swissprots |
Q5JSJ6 Q13976 P14619 A5YM56 E2PU10 Q6P5T7 Q5JP05 B3KSF3
|
| Accessions |
CAB07436 CAB07437 EAW54140 EAW54141 Q13976 AK093436 BAG52715 AK300110 BAG61905 AK313416 AL599933 BC062688 AAH62688 BC127090 AAI27091 BQ445850 BX097700 BX952280 CD723759 D45864 BAA08297 DA150150 DA646702 DA915933 DB138350 DC310312 DC379897 DC381245 EF560730 ABQ59040 GQ129235 ACT64369 GQ129236 ACT64370 Y07512 CAA68810 XM_005269972 XP_005270029 XM_011539952 XP_011538254 NM_001098512 NP_001091982 NM_006258 NP_006249
|
| Function |
Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via sever
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Note=Colocalized with TRPC7 in the plasma membrane. {ECO:0000250}.
|
| Tissue Specificity |
Primarily expressed in lung and placenta. {ECO:0000269|PubMed:9192852}.
|
| Top Pathways |
Gap junction, Long-term depression, Olfactory transduction, Vascular smooth muscle contraction, Salivary secretion
|
![Western Blot: cGK1/PRKG1 Overexpression Lysate (Adult Normal) [NBL1-14782] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for cGK1/PRKG1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3486_cGK1-PRKG1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14782-img0002.jpg)