| Gene Symbol | PRKG1 |
|---|---|
| Entrez Gene | 5592 |
| Alt Symbol | 1, AAT8, PKG, PRKG1B, PRKGR1B, cGK, cGK 1, cGK1, cGKI, cGKI-BETA, cGKI-alpha |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein kinase, cGMP-dependent, type I |
| Other Description | cGMP-dependent protein kinase 1|protein kinase, cGMP-dependent, regulatory, type I, beta |
| Swissprots | Q5JSJ6 Q13976 P14619 A5YM56 E2PU10 Q6P5T7 Q5JP05 B3KSF3 |
| Accessions | CAB07436 CAB07437 EAW54140 EAW54141 Q13976 AK093436 BAG52715 AK300110 BAG61905 AK313416 AL599933 BC062688 AAH62688 BC127090 AAI27091 BQ445850 BX097700 BX952280 CD723759 D45864 BAA08297 DA150150 DA646702 DA915933 DB138350 DC310312 DC379897 DC381245 EF560730 ABQ59040 GQ129235 ACT64369 GQ129236 ACT64370 Y07512 CAA68810 XM_005269972 XP_005270029 XM_011539952 XP_011538254 NM_001098512 NP_001091982 NM_006258 NP_006249 |
| Function | Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via sever |
| Subcellular Location | Cytoplasm {ECO:0000250}. Note=Colocalized with TRPC7 in the plasma membrane. {ECO:0000250}. |
| Tissue Specificity | Primarily expressed in lung and placenta. {ECO:0000269|PubMed:9192852}. |
| Top Pathways | Gap junction, Long-term depression, Olfactory transduction, Vascular smooth muscle contraction, Salivary secretion |
cGKIα/β CRISPR/Cas9 KO Plasmid (h) - sc-401593 from Santa Cruz Biotechnology
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cGKIα/β HDR Plasmid (h) - sc-401593-HDR from Santa Cruz Biotechnology
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cGKIα/β Double Nickase Plasmid (h) - sc-401593-NIC from Santa Cruz Biotechnology
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cGKIα/β Double Nickase Plasmid (h2) - sc-401593-NIC-2 from Santa Cruz Biotechnology
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cGKIα/β CRISPR Activation Plasmid (h) - sc-401593-ACT from Santa Cruz Biotechnology
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cGKIα/β CRISPR Activation Plasmid (h2) - sc-401593-ACT-2 from Santa Cruz Biotechnology
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cGKIα/β Lentiviral Activation Particles (h) - sc-401593-LAC from Santa Cruz Biotechnology
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cGKIα/β Lentiviral Activation Particles (h2) - sc-401593-LAC-2 from Santa Cruz Biotechnology
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cGKIα/β siRNA (h) - sc-35059 from Santa Cruz Biotechnology
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cGKIα/β shRNA Plasmid (h) - sc-35059-SH from Santa Cruz Biotechnology
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cGKIα/β shRNA (h) Lentiviral Particles - sc-35059-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU145811 from Sigma-Aldrich
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MISSION® siRNA - SIHK1864 from Sigma-Aldrich
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MISSION® siRNA - SIHK1863 from Sigma-Aldrich
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MISSION® siRNA - SIHK1862 from Sigma-Aldrich
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MISSION® siRNA - SIHK1866 from Sigma-Aldrich
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MISSION® siRNA - SIHK1865 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17427 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17427 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09895 from Sigma-Aldrich
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PRKG1 siRNA (Human) - CRH3762 from Cohesion Biosciences
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cGK1/PRKG1 RNAi - H00005592-R02 from Novus Biologicals
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shRNA set against Human Prkg1 (NM_006258.3) - SHH382960 from Creative biogene
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Human PRKG1 siRNA - orb264264 from Biorbyt
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PRKG1 shRNA Plasmid (Human) - CHH3762 from Cohesion Biosciences
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