PRKG1

Gene Symbol	PRKG1
Entrez Gene	5592
Alt Symbol	1, AAT8, PKG, PRKG1B, PRKGR1B, cGK, cGK 1, cGK1, cGKI, cGKI-BETA, cGKI-alpha
Species	Human
Gene Type	protein-coding
Description	protein kinase, cGMP-dependent, type I
Other Description	cGMP-dependent protein kinase 1|protein kinase, cGMP-dependent, regulatory, type I, beta
Swissprots	Q5JSJ6 Q13976 P14619 A5YM56 E2PU10 Q6P5T7 Q5JP05 B3KSF3
Accessions	CAB07436 CAB07437 EAW54140 EAW54141 Q13976 AK093436 BAG52715 AK300110 BAG61905 AK313416 AL599933 BC062688 AAH62688 BC127090 AAI27091 BQ445850 BX097700 BX952280 CD723759 D45864 BAA08297 DA150150 DA646702 DA915933 DB138350 DC310312 DC379897 DC381245 EF560730 ABQ59040 GQ129235 ACT64369 GQ129236 ACT64370 Y07512 CAA68810 XM_005269972 XP_005270029 XM_011539952 XP_011538254 NM_001098512 NP_001091982 NM_006258 NP_006249
Function	Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via sever
Subcellular Location	Cytoplasm {ECO:0000250}. Note=Colocalized with TRPC7 in the plasma membrane. {ECO:0000250}.
Tissue Specificity	Primarily expressed in lung and placenta. {ECO:0000269|PubMed:9192852}.
Top Pathways	Gap junction, Long-term depression, Olfactory transduction, Vascular smooth muscle contraction, Salivary secretion

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human cGKI full length protein - ab96403 from Abcam Category Protein Prices $239.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus Species Human

Active human cGKI full length protein - ab80375 from Abcam Category Protein Prices $343.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human cGKI full length protein - ab80413 from Abcam Category Protein Prices $343.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human cGKI protein fragment - ab179487 from Abcam Category Protein Prices $361.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human cGKI full length protein - ab152633 from Abcam Category Protein Source Wheat germ Species Human

Human cGKI protein fragment - ab152634 from Abcam Category Protein Source Wheat germ Species Human

PKG / PRKG1 Antibody Blocking Peptide - LS-E9415 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human cGK1/PRKG1 Protein - H00005592-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human cGK1/PRKG1 Protein - H00005592-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

cGK1/PRKG1 Peptide - P2971 from Novus Biologicals Category Peptide Species Human

cGKI-cGKI-beta-Antibody-C-term-Blocking-peptide - BP8000a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PKG Blocking Peptide - 33R-10767 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

CGK1 - H00005592-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CGK1 - H00005592-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CGK1 - H00005592-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CGK1 - H00005592-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CGK1 - P5620 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

PRKG1 fusion protein - ag16333 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PRKG1 fusion protein - ag17987 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

PKG1beta, Active Human Recombinant Protein - GWB-64BEAA from Genway Biotech Category Protein Prices $410.00 Sizes 10 µg Species Human

PKG1alpha, Active Human Recombinant Protein - GWB-23A92A from Genway Biotech Category Protein Prices $410.00 Sizes 10 µg Species Human

Recombinant Human PRKG1, GST-tagged, Active - PRKG1-413H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human Protein Kinase, cGMP-dependent, Type I - PRKG1-604H from Creative Biomart Category Protein Source Sf9 cells .

Recombinant Human PRKG1, His-tagged - PRKG1-563H from Creative Biomart Category Protein Source Sf9 insect cells.

Recombinant Human PRKG1, His-tagged - PRKG1-564H from Creative Biomart Category Protein Source Sf9 insect cells.

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