PRKG1

Gene Symbol PRKG1
Entrez Gene 5592
Alt Symbol 1, AAT8, PKG, PRKG1B, PRKGR1B, cGK, cGK 1, cGK1, cGKI, cGKI-BETA, cGKI-alpha
Species Human
Gene Type protein-coding
Description protein kinase, cGMP-dependent, type I
Other Description cGMP-dependent protein kinase 1|protein kinase, cGMP-dependent, regulatory, type I, beta
Swissprots Q5JSJ6 Q13976 P14619 A5YM56 E2PU10 Q6P5T7 Q5JP05 B3KSF3
Accessions CAB07436 CAB07437 EAW54140 EAW54141 Q13976 AK093436 BAG52715 AK300110 BAG61905 AK313416 AL599933 BC062688 AAH62688 BC127090 AAI27091 BQ445850 BX097700 BX952280 CD723759 D45864 BAA08297 DA150150 DA646702 DA915933 DB138350 DC310312 DC379897 DC381245 EF560730 ABQ59040 GQ129235 ACT64369 GQ129236 ACT64370 Y07512 CAA68810 XM_005269972 XP_005270029 XM_011539952 XP_011538254 NM_001098512 NP_001091982 NM_006258 NP_006249
Function Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via sever
Subcellular Location Cytoplasm {ECO:0000250}. Note=Colocalized with TRPC7 in the plasma membrane. {ECO:0000250}.
Tissue Specificity Primarily expressed in lung and placenta. {ECO:0000269|PubMed:9192852}.
Top Pathways Gap junction, Long-term depression, Olfactory transduction, Vascular smooth muscle contraction, Salivary secretion

PKG-1 (C8A4) Rabbit mAb - 3248 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C8A4
Western blot analysis of extracts from various cell and tissue types using PKG-1 (C8A4) Rabbit mAb.

PKG-1α (D10G2) Rabbit mAb - 13511 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D10G2
Western blot analysis of extracts from COS-7 cells, mock transfected (-) or transfected with constructs expressing full-length human PKG-1α (hPKG-1α; +) or PKG-1β (hPKG-1β; +), using PKG-1α (D10G2) Rabbit mAb (upper) or PKG-1 (C8A4) Rabbit mAb #3248 (lower).

cGKIα (F-5) - sc-393987 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cGKIα (F-5): sc-393987. Western blot analysis of cGKIα expression in HISM (A), SK-N-MC (B) and U-251-MG (C) whole cell lysates.

cGKIα (N-16) - sc-10335 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
cGKIα (N-16): sc-10335. Western blot analysis of cGKIα expression in HISM whole cell lysate.

cGKIα (E-17) - sc-10338 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
cGKIα (E-17): sc-10338. Western blot analysis of cGKIα expression in HISM whole cell lysate.

cGKIα/β (E-1) - sc-271765 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cGKIα/β (E-1): sc-271765. Western blot analysis of cGKIα/β expression in HISM whole cell lysate.

cGKIα/β (G-3) - sc-271766 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cGKIα/β (G-3): sc-271766. Western blot analysis of cGKIα/β expression in HISM whole cell lysate.

cGKIα/β (T-19) - sc-10343 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

cGKIα/β (H-100) - sc-25429 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
cGKIα/β (H-100): sc-25429. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing cytoplasmic and nuclear staining of glandular cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

cGKIβ (E-20) - sc-10342 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

cGKIβ (L-16) - sc-10341 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
cGKIβ (L-16): sc-10341. Western blot analysis of cGKIβ expression in A-10 whole cell lysate.

Anti-cGKI antibody - ab111930 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-cGKI antibody - ab154724 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-cGKI antibody (ab154724) at 1/2000 dilutionLane 1 : NIH-3T3 whole cell lysateLane 2 : JC whole cell lysateLysates/proteins at 30 µg per lane.

Anti-cGKI antibody - ab69532 from Abcam

Prices $376.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-cGKI antibody (ab69532) at 1/1000 dilutionLane 1 : Molecular weight markerLane 2 : Tissue lysate prepared from Mouse brainLane 3 : Tissue lysate prepared from Rat brainLane 4 : Cell lysates prepared from EKS4 cellsLane 5 : Cell lysate prepared from HS67 cells

Anti-cGKI antibody - ab121266 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent staining of Human cell line U-251MG shows positivity in cytoplasm. Recommended concentration of ab121266 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Anti-cGKI antibody - ab57437 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57437 cGKI antibody at 1ug/ml.

Anti-cGKI antibody - ab57439 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57439 cGKI antibody at 1ug/ml.

Anti-cGKI antibody [9A4] - ab119000 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 9A4
All lanes : Anti-cGKI antibody [9A4] (ab119000) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY cGKI cDNALysates/proteins at 5 µg per lane.

Anti-cGKI antibody - Carboxyterminal end - ab37709 from Abcam

Prices $379.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical detection of PKG expression in formalin-fixed and paraffin-embedded human hepatocarcinoma tissue using 1/50 ab37709.

Anti-PKG / PRKG1 Antibody - LS-C343645 from LifeSpan Bioscience

Prices $425.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal
Western blot: Lane 1: MW marker, Lane 2: HeLa cell lysate, Lane 3: Rat brain tissue extract, Lane 4: MDBK cell lysate.

Anti-PKG / PRKG1 Antibody (clone 9G4) - LS-C115186 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 9G4
IHC of paraffin-embedded pancreas tissue using anti-PRKG1 mouse monoclonal antibody. (Dilution 1:50).

Anti-PKG / PRKG1 Antibody - LS-C332170 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded rat lung using PRKG1 antibody at dilution of 1:100 (400x lens).

Anti-PKG / PRKG1 Antibody (aa657-671) IHC-plus™ - LS-B2219 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PRKG1 / CGKI antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2219 concentration 10 ug/ml.

Anti-PKG / PRKG1 Antibody (clone 2B3) IHC-plus™ - LS-B4398 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2B3
Anti-PRKG1 / CGKI antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4398 concentration 5 ug/ml.

Anti-PKG / PRKG1 Antibody (aa4-17) - LS-C26172 from LifeSpan Bioscience

Prices $355.00
Sizes 25 µg
Host Rabbit
Clonality Polyclonal
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