NEURL1

Gene Symbol NEURL1
Entrez Gene 9148
Alt Symbol NEUR1, NEURL, RNF67, bA416N2.1, neu, neu-1
Species Human
Gene Type protein-coding
Description neuralized E3 ubiquitin protein ligase 1
Other Description E3 ubiquitin-protein ligase NEURL1|RING finger protein 67|h-neuralized 1|neuralized homolog|neuralized-like protein 1A
Swissprots Q5TDR3 Q9H463 O76050 Q5TDR2 Q8TAN0
Accessions CCQ43253 EAW49628 EAW49629 EAW49630 O76050 AF029729 AAD01887 AK299620 BAG61548 BC026336 AAH26336 U87864 AAC17474 XM_005270269 XP_005270326 XM_005270270 XP_005270327 XM_011540331 XP_011538633 XM_011540332 XP_011538634 XM_011540333 XP_011538635 XM_011540334 XP_011538636 XM_011540335 XP_011538637 XR_945866 NM_004210 NP_004201
Function Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element- binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway. {ECO:0000269|PubMed:20847082}.
Subcellular Location Cytoplasm, perinuclear region {ECO:0000269|PubMed:11585928, ECO:0000269|PubMed:20847082}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Perikaryon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons (By similarity). Colocalized with JAG1 at the cell surface. {ECO:0000250}.
Tissue Specificity Expressed in brain, testis, pituitary gland, pancreas and bone marrow. Also poorly expressed in an malignant astrocytomas and several neuroectodermal tumor cell lines. Weakly expressed in medulloblastoma (MB) compared with normal cerebellar tissues. {ECO:0000269|PubMed:11585928, ECO:0000269|PubMed:9519875}.

NEURL (N-15) - sc-163133 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NEURL (N-15): sc-163133. Western blot analysis of NEURL expression in Hep G2 whole cell lysate.

Anti-NEURL antibody - ab74262 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab74262 stained MCF7 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab74262, 10µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-NEURL antibody - ab175940 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain tissue labeling NEURL with ab175940 at 1/50 dilution followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-NEURL1 / NEURL Antibody (aa165-194, AP) - LS-C237978 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEURL1 / NEURL Antibody (aa165-194, APC) - LS-C237979 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEURL1 / NEURL Antibody (aa165-194, Biotin) - LS-C237981 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEURL1 / NEURL Antibody (aa165-194, FITC) - LS-C237980 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEURL1 / NEURL Antibody (aa165-194, PE) - LS-C237984 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEURL1 / NEURL Antibody (aa165-194, Azide-free, HRP) - LS-C248902 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEURL1 / NEURL Antibody (aa165-194) - LS-C329881 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEURL1 / NEURL Antibody (aa107-156) - LS-C110745 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
NEURL antibody LS-C110745 Western blot of Fetal Small Intestine lysate.

Anti-NEURL1 / NEURL Antibody (aa219-268) - LS-C120142 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from MCF-7 cells, using NEURL1 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-NEURL1 / NEURL Antibody (Val250) - LS-C177479 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of Neuralized-1 (V250) pAb in paraffin-embedded human brain tissue.

Anti-NEURL1 / NEURL Antibody (aa158-186) - LS-C164835 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human brain tissue reacted with NEURL Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

NEU-1/Sialidase-1 Antibody - NBP1-87755 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: NEU-1/Sialidase-1 Antibody [NBP1-87755] - Analysis in human cell line RPMI-8226.

NEU-1/Sialidase-1 Antibody - NBP1-87756 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: NEU-1/Sialidase-1 Antibody [NBP1-87756] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

NEURL Antibody - NBP1-92177 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: NEURL Antibody [NBP1-92177] - Staining of human pancreas shows moderate cytoplasmic positivity in exocrine glandular cells.

NEURL/RNF67 Polyclonal Antibody - bs-11897R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NEURL/RNF67 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11897R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NEURL/RNF67 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11897R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NEURL/RNF67 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11897R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NEURL/RNF67 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11897R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NEURL/RNF67 Polyclonal Antibody, Cy3 Conjugated - bs-11897R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NEURL/RNF67 Polyclonal Antibody, Cy5 Conjugated - bs-11897R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NEURL/RNF67 Polyclonal Antibody, Cy5.5 Conjugated - bs-11897R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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